The effect of enzyme replacement therapy on bone crisis and bone pain in patients with type 1 Gaucher disease

Joel Charrow*, B. Dulisse, G. A. Grabowski, N. J. Weinreb

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

The effect of enzyme replacement therapy (ERT) on bone crisis and bone pain was investigated in patients with Gaucher disease (GD) type 1 followed over 4 years. Data from the International Collaborative Gaucher Group Gaucher Registry were used. Only patients with bone crisis and/or bone pain data for 1 year prior to ERT, and for each of 3 years after the start of ERT, were included. Bone crises were reported in 17% of patients during the year before starting ERT. The frequencies of bone crises decreased to 5%, <1% and 3% for 1, 2, and 3 years after initiation of treatment, respectively (p < 0.0001). Bone pain followed a similar pattern of response. Bone pain was reported in 49% of patients the year before treatment and decreased to 30% in the first year, 29% in the second year, and 30% in the third year of ERT (p < 0.0001). ERT is associated with a reduction in bone crisis and bone pain in patients with GD type 1. This study shows that significant improvements in symptoms of skeletal disease are achievable clinical outcomes and treatment goals in GD type 1.

Original languageEnglish (US)
Pages (from-to)205-211
Number of pages7
JournalClinical Genetics
Volume71
Issue number3
DOIs
StatePublished - Mar 1 2007

Keywords

  • Bone crisis
  • Bone pain
  • Enzyme replacement therapy
  • Gaucher disease
  • Imiglucerase

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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