The effect of gestational age on amniotic fluid glucose in pregnancy complicated by diabetes mellitus

Sharon L Dooley*, Boyd E Metzger, Richard Depp, Norbert Freinkel, Richard L. Phelps

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Amniotic fluid glucose was measured in 189 amniotic fluid samples from 117 well-controlled Class A to F diabetic pregnant women from 32 to 40 weeks' gestation. A simultaneous maternal plasma glucose level was determined at each amniocentesis. Samples were obtained with the mother in the fasting or nonfasting (3.8 hours after breakfast) state. Amniotic fluid glucose correlated significantly with simultaneous maternal glucose (r = 0.562; p = 0.001). A significant downward linear trend of mean amniotic fluid glucose with advancing gestational age was demonstrated (p < 0.01). No trend of mean simultaneous maternal glucose with gestational age was seen. These results were not affected by maternal prandial status at the time of amniocentesis. It is concluded that amniotic fluid glucose decreases with advancing gestational age in well-controlled diabetic pregnant women independent of maternal glycemic levels. Studies of amniotic fluid glucose and/or its relationship to other metabolic hormones must take this into account.

Original languageEnglish (US)
Pages (from-to)492-496
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume142
Issue number5
DOIs
StatePublished - Mar 1 1982

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'The effect of gestational age on amniotic fluid glucose in pregnancy complicated by diabetes mellitus'. Together they form a unique fingerprint.

Cite this