The effect of glucagon-induced gastric relaxation on TLOSR frequency

H. Y. Chang, J. E. Pandolfino, G. Shi, G. E. Boeckxstaens, R. J. Joehl, Peter J. Kahrilas*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

This study aimed to determine the effect of glucagon-induced gastric relaxation on the frequency of transient lower oesophageal sphincter relaxations (TLOSRs). Eight normal subjects (four male, age 18-52 y) were studied after a 6-h fast using a combined manometric barostat assembly. The recording was divided into two 1-h sessions: (1) a baseline period with the barostat set at minimal distending pressure (MDP) + 2 mmHg and (2) a period with continuous glucagon or placebo infusion with barostat set at MDP + 2 mmHg. Patients were studied on two different days and randomly received glucagon (4.8 μg kg-1 bolus followed by 9.6 μg kg-1 h-1 infusion) on 1 day and placebo (saline) on another. Lower oesophageal sphincter (LOS) pressure, frequency of TLOSRs, and barostat bag volumes were determined for both placebo and glucagon infusion. Glucagon induced significant fundal relaxation compared with placebo (P < 0.05) and significantly decreased baseline LEOS pressure (P < 0.05). The frequency of TLOSRs was not altered by glucagon infusion compared with placebo. Despite causing substantial proximal stomach relaxation, glucagon did not increase TLOSR frequency. This suggests that the relevant gastric mechanoreceptors responsible for triggering TLOSRs do not respond to passive elongation.

Original languageEnglish (US)
Pages (from-to)3-8
Number of pages6
JournalNeurogastroenterology and Motility
Volume15
Issue number1
DOIs
StatePublished - Feb 2003

Keywords

  • Gastro-oesophageal reflux disease
  • Glucagon
  • Transient lower oesophageal sphincter relaxations

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology

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