The Effect of Hematocrit on Peritoneal Transport

S. M. Korbet, E. F. Vonesh, C. A. Firanek

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Eight stable patients, from our institution, on continuous ambulatory peritoneal dialysis (CAPD) were entered into a multicenter, randomized, double-blind, placebo-controlled study with erythropoietin (EPO). To assess the effect of hematocrit on peritoneal solute transport, we performed peritoneal equilibration tests (PET) on each patient on a quarterly basis throughout the study. Patients on EPO had a significant increase in hematocrit at 3 (32% ± 5%), 6 (32% ± 2%), and 9 (38% ± 3%) months compared with baseline (22% ± 4%). The D/P creatinine (Cr) at 4 hours was also significantly reduced in the patients on EPO at 3 (.70 ± .1), 6 (.66 ± .1), and 9 (.66 ± .12) months when compared with baseline (.76 ± .11). No significant change in D/Do glucose at 4 hours or in the 4-hour ultrafiltrate (except at 9 months) was found. Based on mixed-effects regression analysis, the 4-hour D/P Cr, peritoneal Cr clearance, and Cr mass transfer area coefficient significantly decreased as hematocrit levels increased. The 4-hour D/Do glucose and the 4-hour ultrafiltrate both demonstrated a positive correlation with increasing hematocrit levels, but this did not reach statistical significance. Although larger studies are needed, it appears that increasing hematocrit levels may negatively affect peritoneal solute transport in CAPD patients as determined by PET.

Original languageEnglish (US)
Pages (from-to)573-578
Number of pages6
JournalAmerican Journal of Kidney Diseases
Volume18
Issue number5
DOIs
StatePublished - 1991

Keywords

  • Peritoneal equilibration test
  • erythropoietin
  • peritoneal dialysis

ASJC Scopus subject areas

  • Nephrology

Fingerprint Dive into the research topics of 'The Effect of Hematocrit on Peritoneal Transport'. Together they form a unique fingerprint.

Cite this