The authors confirmed that LTD4 is a potent bronchoconstrictor which has a rapid onset of action and a prolonged effect but no delayed effect. The bronchoconstriction produced by LTD4 does not appear to be limited to small airways, since sensitive tests of both large (SGaw) and small (V̇30P) airway function changed in a parallel fashion. As seen with other bronchoconstrictor agents, rhinitis subjects were more sensitive to LTD4 than normal subjects, and asthmatic subjects were more sensitive than rhinitis subjects. Finally individuals in all 3 groups were several hundred times more sensitive to LTD4 than methacholine and demonstrated a significant relationship between the LTD4 and methacholine concentrations required to produce equivalent bronchoconstriction.
|Original language||English (US)|
|Issue number||5 SUPPL.|
|State||Published - 1985|
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Critical Care and Intensive Care Medicine
- Cardiology and Cardiovascular Medicine