The effect of ketanserin on blood pressure and platelets during cardiopulmonary bypass

P. R. Lichtenthal, L. D. Wade, E. C. Rossi

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Ketanserin, a serotonin antagonist, was used to control blood pressure during cardiopulmonary bypass in 12 patients having cardiac surgery. The drug was administered as a 10 mg bolus followed by a continuous infusion of either 40, 80, or 120 mg/hr to maintain mean arterial blood pressure below 70 mm Hg. There were 16 hypertensive episodes of which 15 (93.7%) were successfully controlled with ketanserin. Mean arterial prressure decreased significantly from an average of 72 ± 3 to 52 ± 9 mm Hg after 1 min. The effect that ketanserin had on platelets was also evaluated. Neither adverse nor salutary effects were seen in the platelet count, though a significant inhibition of serotonin-induced platelet aggregation was observed. Ketanserin proved effective for controlling hypertension during cardiopulmonary bypass but, despite inhibition of serotonin-induced platelet aggregation, it did not prevent thrombocytopenia.

Original languageEnglish (US)
Pages (from-to)1151-1154
Number of pages4
JournalAnesthesia and analgesia
Volume66
Issue number11
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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