The effect of magnesium sulfate tocolysis on the fetal biophysical profile

Alan M. Peaceman*, Bruce A. Meyer, James A. Thorp, Valerie M. Parisi, Robert K. Creasy

*Corresponding author for this work

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The biophysical profile has proved to be a valuable tool for the assessment of fetal well-being, independent of gestational age. Magnesium sulfate is commonly used as a tocolytic agent, yet relatively little is known about its effects on the biophysical activities of the fetus. To investigate the effects of magnesium sulfate on the biophysical profile, we performed serial studies on patients who received tocolytic therapy with this agent because of preterm labor. A total of 16 women with 22 fetuses at 26 to 34 weeks' gestation in spontaneous preterm labor were studied. An initial biophysical profile was performed at the time of admission, and a second examination was performed when maternal serum magnesium levels reached 6 to 8 mg/dl. On admission all fetuses had reactive nonstress test results and 21 of 22 (95%) demonstrated sustained fetal breathing movements. With magnesium sulfate tocolysis, 50% of fetuses had nonreactive nonstress test results, and only 4 of 22 (18%) demonstrated sustained fetal breathing movements. Fetal tone, gross body movements, and amniotic fluid volume were found to be unaffected by magnesium sulfate tocolysis.

Original languageEnglish (US)
Pages (from-to)771-774
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Volume161
Issue number3
DOIs
StatePublished - Jan 1 1989

Fingerprint

Tocolysis
Magnesium Sulfate
Fetus
Fetal Movement
Premature Obstetric Labor
Respiration
Tocolytic Agents
Body Fluids
Amniotic Fluid
Magnesium
Gestational Age
Mothers
Pregnancy
Serum

Keywords

  • Magnesium sulfate
  • biophysical profile
  • preterm labor

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Peaceman, Alan M. ; Meyer, Bruce A. ; Thorp, James A. ; Parisi, Valerie M. ; Creasy, Robert K. / The effect of magnesium sulfate tocolysis on the fetal biophysical profile. In: American Journal of Obstetrics and Gynecology. 1989 ; Vol. 161, No. 3. pp. 771-774.
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The effect of magnesium sulfate tocolysis on the fetal biophysical profile. / Peaceman, Alan M.; Meyer, Bruce A.; Thorp, James A.; Parisi, Valerie M.; Creasy, Robert K.

In: American Journal of Obstetrics and Gynecology, Vol. 161, No. 3, 01.01.1989, p. 771-774.

Research output: Contribution to journalArticle

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