The effect of mescaline, 3,4-dimethoxyphenethylamine and 2,5-dimethoxy-4-methylamphetamine on rat plasma prolactin: Evidence for serotonergic mediation

Herbert Y. Meltzer*, Richard G. Fessler, Miljana Simonovic, Victor S. Fang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Mescaline, 3,4-dimethoxyphenethylamine (DMPEA) or 2,5-dimethoxy-4-methylamphetamine (DOM) was administered to male Sprague-Dawley rats, alone or in combination with para-chlorophenylalanine (PCPA), an inhibitor of serotonin (5-HT) synthesis, or methysergide, a 5-HT receptor blocker. All three compounds increased plasma prolactin (PRL) levels. These increases were potentiated by PCPA and blocked by methysergide. Pretreatment with alpha-methylparatyrosine (AMPT), an inhibitor of catecholamine synthesis, resulted in an increase in plasma PRL equal to the additive effects of the independent administration of mescaline, DMPEA, or DOM plus the AMPT-induced response. The results suggest that mescaline, DMPEA and DOM may be exerting their effects on rat plasma PRL through direct stimulation of serotonin receptors. These results further demonstrate the ability of PCPA to rapidly induce supersensitivity of the 5-HT receptors which stimulate PRL secretion.

Original languageEnglish (US)
Pages (from-to)1185-1192
Number of pages8
JournalLife Sciences
Volume23
Issue number11
DOIs
StatePublished - Sep 18 1978

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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