TY - JOUR
T1 - The effect of short-term total parenteral nutrition on hepatic function in the human neonate
T2 - A prospective randomized study demonstrating alteration of hepatic canalicular function
AU - Black, Dennis D.
AU - Suttle, E. Amy
AU - Whitington, Peter F.
AU - Whitington, Gene L.
AU - Korones, Sheldon D.
N1 - Funding Information:
From the Department of Pediatrics, Division of Gastroenterology and Neonatal Medicine, University of Tennessee Center for the Health Sciences, the LeBonheur Children's Medical Center and the Newborn Center, City of Memphis" Hospital. Dr. P. K Whitington suppported in part by New Faculty Grant (U-00039)from the University of Tennessee Center J or the Health Sciences'. *Reprint address: UTCHS Pediatric Research Laboratory, 951 Court Ave.--555 Dobbs, Memphis, TN 38163,
PY - 1981/9
Y1 - 1981/9
N2 - Twenty-one infants who were candidates for TPN because of respiratory disease were randomized into experimental (TPN) and control (glucose-electrolyte) groups. Serum GOT, GPT, GGTP, 5′ nucleotidase, total, direct, and conjugated (ethyl anthranilate-reactive) bilirubin, and bile salt concentrations were determined at entry into the study and at one week. One week of TPN caused significant elevations of GGTP, 5′-N, and EA bilirubin values, whereas SGOT, SGPT, SBS, and total and direct bilirubin were unaffected. Addition of a lipid infusion to TPN did not alter these differences. These data are interpreted as showing: (1) amino acid infusion has an early effect on hepatic function which is independent of the many diseases for which this therapy is used and of the concomitant use of lipid; (2) the initial effect appears to be on the canalicular membrane; and (3) the sinusoidal membrane is apparently unaffected by one week of TPN.
AB - Twenty-one infants who were candidates for TPN because of respiratory disease were randomized into experimental (TPN) and control (glucose-electrolyte) groups. Serum GOT, GPT, GGTP, 5′ nucleotidase, total, direct, and conjugated (ethyl anthranilate-reactive) bilirubin, and bile salt concentrations were determined at entry into the study and at one week. One week of TPN caused significant elevations of GGTP, 5′-N, and EA bilirubin values, whereas SGOT, SGPT, SBS, and total and direct bilirubin were unaffected. Addition of a lipid infusion to TPN did not alter these differences. These data are interpreted as showing: (1) amino acid infusion has an early effect on hepatic function which is independent of the many diseases for which this therapy is used and of the concomitant use of lipid; (2) the initial effect appears to be on the canalicular membrane; and (3) the sinusoidal membrane is apparently unaffected by one week of TPN.
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U2 - 10.1016/S0022-3476(81)80346-0
DO - 10.1016/S0022-3476(81)80346-0
M3 - Article
C2 - 6115001
AN - SCOPUS:0019478795
VL - 99
SP - 445
EP - 449
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 3
ER -