The effect of STN DBS on modulating brain oscillations: consequences for motor and cognitive behavior

Fabian J. David*, Miranda J. Munoz, Daniel M. Corcos

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

In this review, we highlight Professor John Rothwell’s contribution towards understanding basal ganglia function and dysfunction, as well as the effects of subthalamic nucleus deep brain stimulation (STN DBS). The first section summarizes the rate and oscillatory models of basal ganglia dysfunction with a focus on the oscillation model. The second section summarizes the motor, gait, and cognitive mechanisms of action of STN DBS. In the final section, we summarize the effects of STN DBS on motor and cognitive tasks. The studies reviewed in this section support the conclusion that high-frequency STN DBS improves the motor symptoms of Parkinson’s disease. With respect to cognition, STN DBS can be detrimental to performance especially when the task is cognitively demanding. Consolidating findings from many studies, we find that while motor network oscillatory activity is primarily correlated to the beta-band, cognitive network oscillatory activity is not confined to one band but is subserved by activity in multiple frequency bands. Because of these findings, we propose a modified motor and associative/cognitive oscillatory model that can explain the consistent positive motor benefits and the negative and null cognitive effects of STN DBS. This is clinically relevant because STN DBS should enhance oscillatory activity that is related to both motor and cognitive networks to improve both motor and cognitive performance.

Original languageEnglish (US)
Pages (from-to)1659-1676
Number of pages18
JournalExperimental Brain Research
Volume238
Issue number7-8
DOIs
StatePublished - Aug 1 2020

Keywords

  • Beta-band oscillatory activity
  • Cognitive network
  • Models of basal ganglia dysfunction
  • Motor network
  • Parkinson’s disease
  • Subthalamic nucleus deep brain stimulation

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'The effect of STN DBS on modulating brain oscillations: consequences for motor and cognitive behavior'. Together they form a unique fingerprint.

Cite this