The effect of thyroid- and of dinitrophenol-induced hypermetabolism on plasma and tissue lipids and atherosclerosis in the cholesterol-fed chick

J. Stamler*, E. N. Silber, A. J. Miller, L. Akman, C. Bolene, L. N. Katz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

1. 1. Desiccated thyroid has a partial inhibitory effect on cholesterol-induced hypercholesterolemia and atherosclerosis in the chick. It also lowers the hyperphospholipidemia and hyperlipemia of cholesterol-feeding, decreases aortic cholesterosis, and is effective as a lipotropic agent against the cholesterol-type fatty liver. 2. 2. By contrast, the hypermetabolism-inducing agent dinitrophenol has little or no effect on plasma or tissue lipid levels. It is also ineffective as a prophylactic agent against cholesterol-induced atherosclerosis in the chick. 3. 3. It is concluded that the effects of thyroid on lipid metabolism and atherosclerosis are not mere nonspecific by-products of the induced generalized increase in metabolic rate. Thyroid hormone and the lipids appear to be closely linked metabolically. The hormone apparently influences cholesterol metabolism and atherosclerosis via specific intermediate biochemical reactions in which it participates. 4. 4. Cholesterol-induced atherosclerosis in the chick may develop with little or no increase in the hepatic total cholesterol concentration.

Original languageEnglish (US)
Pages (from-to)351-361
Number of pages11
JournalThe Journal of laboratory and clinical medicine
Volume35
Issue number3
StatePublished - Mar 1 1950

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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