The Effectiveness of Fibrin Glue Sealant for Reducing Experimental Pulmonary Air Leak

P. M. McCarthy, V. F. Trastek, D. G. Bell, G. R. Buttermann, J. M. Piehler, W. S. Payne, L. H. Weiland, P. C. Pairolero

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

The effectiveness of fibrin glue as a biological sealant for pulmonary air leaks was determined in 16 dogs. A standardized pleural defect was made in the left lower lobe, and the quantity of air passing through a chest tube was assessed with a Collins respirometer. For the 8 randomly assigned control animals, the air leak decreased over 90 minutes from a mean of 1.4 L/min to a mean of 1.1 L/min (mean decrease, 19.8%). In the 8 randomly assigned fibrin glue-treated animals, the air leak decreased from a mean of 2.1 L/min to a mean of 0.5 L/min (mean decrease, 80.8%) (p < 0.0001). Postoperative evaluation of survivors disclosed no increased adhesions in the glue-treated animals and complete resorption of the glue at 3 months. We conclude that in this animal model, fibrin glue reduced the size of pulmonary air leaks in the early period after thoracotomy and did not lead to increased intrapleural adhesions.

Original languageEnglish (US)
Pages (from-to)203-205
Number of pages3
JournalAnnals of Thoracic Surgery
Volume45
Issue number2
DOIs
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'The Effectiveness of Fibrin Glue Sealant for Reducing Experimental Pulmonary Air Leak'. Together they form a unique fingerprint.

Cite this