Acetaldehyde in the range of 1 to 5 mM increases the rate and extent of swelling of rat liver mitochondria with either DL-3-hydroxybutyrate or succinate as substrate. Higher concentrations of acetaldehyde first increase the rate of swelling and then completely inhibit swelling. Exposure of mitochondria to 5 mM acetaldehyde does not alter the requirements of swelling for energy and inorganic phosphate. The results demonstrate that acetaldehyde is capable of altering the kinetics of swelling under conditions which prevent the oxidation of acetaldehyde.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)