The effects of acetaldehyde on the kinetics of the energy-dependent phosphate-induced swelling of rat liver mitochondria

Keith H. Byington; June Z. Yeh

doi:10.1016/0024-3205(72)90233-0

The effects of acetaldehyde on the kinetics of the energy-dependent phosphate-induced swelling of rat liver mitochondria

Keith H. Byington^*, June Z. Yeh

^*Corresponding author for this work

Pharmacology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Acetaldehyde in the range of 1 to 5 mM increases the rate and extent of swelling of rat liver mitochondria with either DL-3-hydroxybutyrate or succinate as substrate. Higher concentrations of acetaldehyde first increase the rate of swelling and then completely inhibit swelling. Exposure of mitochondria to 5 mM acetaldehyde does not alter the requirements of swelling for energy and inorganic phosphate. The results demonstrate that acetaldehyde is capable of altering the kinetics of swelling under conditions which prevent the oxidation of acetaldehyde.

Original language	English (US)
Pages (from-to)	301-307
Number of pages	7
Journal	Life Sciences
Volume	11
Issue number	6 PART 1
DOIs	https://doi.org/10.1016/0024-3205(72)90233-0
State	Published - Mar 15 1972

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(72)90233-0

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title = "The effects of acetaldehyde on the kinetics of the energy-dependent phosphate-induced swelling of rat liver mitochondria",

abstract = "Acetaldehyde in the range of 1 to 5 mM increases the rate and extent of swelling of rat liver mitochondria with either DL-3-hydroxybutyrate or succinate as substrate. Higher concentrations of acetaldehyde first increase the rate of swelling and then completely inhibit swelling. Exposure of mitochondria to 5 mM acetaldehyde does not alter the requirements of swelling for energy and inorganic phosphate. The results demonstrate that acetaldehyde is capable of altering the kinetics of swelling under conditions which prevent the oxidation of acetaldehyde.",

author = "Byington, {Keith H.} and Yeh, {June Z.}",

note = "Funding Information: Furthermore, the mitochondrial swelling reported to occur in rats dosed with *This investigation was supported by a research grant from the Licensed Beverage Industries, Inc . and by USPH General Research Support Funds number FR 5387-10 . Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

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T1 - The effects of acetaldehyde on the kinetics of the energy-dependent phosphate-induced swelling of rat liver mitochondria

AU - Byington, Keith H.

AU - Yeh, June Z.

N1 - Funding Information: Furthermore, the mitochondrial swelling reported to occur in rats dosed with *This investigation was supported by a research grant from the Licensed Beverage Industries, Inc . and by USPH General Research Support Funds number FR 5387-10 . Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 1972/3/15

Y1 - 1972/3/15

N2 - Acetaldehyde in the range of 1 to 5 mM increases the rate and extent of swelling of rat liver mitochondria with either DL-3-hydroxybutyrate or succinate as substrate. Higher concentrations of acetaldehyde first increase the rate of swelling and then completely inhibit swelling. Exposure of mitochondria to 5 mM acetaldehyde does not alter the requirements of swelling for energy and inorganic phosphate. The results demonstrate that acetaldehyde is capable of altering the kinetics of swelling under conditions which prevent the oxidation of acetaldehyde.

AB - Acetaldehyde in the range of 1 to 5 mM increases the rate and extent of swelling of rat liver mitochondria with either DL-3-hydroxybutyrate or succinate as substrate. Higher concentrations of acetaldehyde first increase the rate of swelling and then completely inhibit swelling. Exposure of mitochondria to 5 mM acetaldehyde does not alter the requirements of swelling for energy and inorganic phosphate. The results demonstrate that acetaldehyde is capable of altering the kinetics of swelling under conditions which prevent the oxidation of acetaldehyde.

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JO - Life Sciences

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ER -

The effects of acetaldehyde on the kinetics of the energy-dependent phosphate-induced swelling of rat liver mitochondria

Abstract

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