The effects of acetaldehyde on the kinetics of the energy-dependent phosphate-induced swelling of rat liver mitochondria

Keith H. Byington*, June Z. Yeh

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Acetaldehyde in the range of 1 to 5 mM increases the rate and extent of swelling of rat liver mitochondria with either DL-3-hydroxybutyrate or succinate as substrate. Higher concentrations of acetaldehyde first increase the rate of swelling and then completely inhibit swelling. Exposure of mitochondria to 5 mM acetaldehyde does not alter the requirements of swelling for energy and inorganic phosphate. The results demonstrate that acetaldehyde is capable of altering the kinetics of swelling under conditions which prevent the oxidation of acetaldehyde.

Original languageEnglish (US)
Pages (from-to)301-307
Number of pages7
JournalLife Sciences
Volume11
Issue number6 PART 1
DOIs
StatePublished - Mar 15 1972

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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