The effects of acute uremia on plasma glucose, insulin and growth hormone in the rat

M. Nitzan; B. E. Metzger; J. F. Wilber

doi:10.1016/0024-3205(71)90149-4

The effects of acute uremia on plasma glucose, insulin and growth hormone in the rat

M. Nitzan^*, B. E. Metzger, J. F. Wilber

^*Corresponding author for this work

Medicine, Endocrinology Division

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The effects of acute uremic syndrome upon plasma glucose, insulin and growth hormone were evaluated in the fasted rat 24 hours following bilateral nephrectomy. Appropriate control studies were instituted to correct for the non-specific effects of surgical intervention. The mean levels of plasma glucose, IRI and GH, as well as insulin to glucose ratio were significantly higher in the uremic animals than in the sham-operated controls. The fasting hyperglycemia in the presence of high levels of circulating IRI observed in the nephrectomized rats suggest impaired responsiveness of the peripheral tissues to the action of insulin. Since similar findings have been reported in chronic renal failure in the human, it is suggested that the acutely uremic rat might be employed as an experimental model for further elucidating the underlying mechanisms of glucose intolerance in uremia.

Original language	English (US)
Pages (from-to)	671-676
Number of pages	6
Journal	Life Sciences
Volume	10
Issue number	12 PART 2
DOIs	https://doi.org/10.1016/0024-3205(71)90149-4
State	Published - Jun 22 1971

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(71)90149-4

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title = "The effects of acute uremia on plasma glucose, insulin and growth hormone in the rat",

abstract = "The effects of acute uremic syndrome upon plasma glucose, insulin and growth hormone were evaluated in the fasted rat 24 hours following bilateral nephrectomy. Appropriate control studies were instituted to correct for the non-specific effects of surgical intervention. The mean levels of plasma glucose, IRI and GH, as well as insulin to glucose ratio were significantly higher in the uremic animals than in the sham-operated controls. The fasting hyperglycemia in the presence of high levels of circulating IRI observed in the nephrectomized rats suggest impaired responsiveness of the peripheral tissues to the action of insulin. Since similar findings have been reported in chronic renal failure in the human, it is suggested that the acutely uremic rat might be employed as an experimental model for further elucidating the underlying mechanisms of glucose intolerance in uremia.",

author = "M. Nitzan and Metzger, {B. E.} and Wilber, {J. F.}",

note = "Funding Information: THS occurrence of glucose intolerance in chronic renal failure has been estenaively documented (1,2). In recent years, ae the life of the uremic subject has been lengthened by long-term, inteimittnat dialysis and renal trans plantation, this subject has received increasing attention. Limited information, however, is available on the effects of acute uremia on carbohydrate *This work was supported in part by Research Grant AM-10699 sad Training Grant AM-05071 from the National Institute of Arthritis and Metabolic Diseases, U. S.P,H.S Betheeda, Maryland.",

year = "1971",

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doi = "10.1016/0024-3205(71)90149-4",

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AU - Nitzan, M.

AU - Metzger, B. E.

AU - Wilber, J. F.

N1 - Funding Information: THS occurrence of glucose intolerance in chronic renal failure has been estenaively documented (1,2). In recent years, ae the life of the uremic subject has been lengthened by long-term, inteimittnat dialysis and renal trans plantation, this subject has received increasing attention. Limited information, however, is available on the effects of acute uremia on carbohydrate *This work was supported in part by Research Grant AM-10699 sad Training Grant AM-05071 from the National Institute of Arthritis and Metabolic Diseases, U. S.P,H.S Betheeda, Maryland.

PY - 1971/6/22

Y1 - 1971/6/22

N2 - The effects of acute uremic syndrome upon plasma glucose, insulin and growth hormone were evaluated in the fasted rat 24 hours following bilateral nephrectomy. Appropriate control studies were instituted to correct for the non-specific effects of surgical intervention. The mean levels of plasma glucose, IRI and GH, as well as insulin to glucose ratio were significantly higher in the uremic animals than in the sham-operated controls. The fasting hyperglycemia in the presence of high levels of circulating IRI observed in the nephrectomized rats suggest impaired responsiveness of the peripheral tissues to the action of insulin. Since similar findings have been reported in chronic renal failure in the human, it is suggested that the acutely uremic rat might be employed as an experimental model for further elucidating the underlying mechanisms of glucose intolerance in uremia.

AB - The effects of acute uremic syndrome upon plasma glucose, insulin and growth hormone were evaluated in the fasted rat 24 hours following bilateral nephrectomy. Appropriate control studies were instituted to correct for the non-specific effects of surgical intervention. The mean levels of plasma glucose, IRI and GH, as well as insulin to glucose ratio were significantly higher in the uremic animals than in the sham-operated controls. The fasting hyperglycemia in the presence of high levels of circulating IRI observed in the nephrectomized rats suggest impaired responsiveness of the peripheral tissues to the action of insulin. Since similar findings have been reported in chronic renal failure in the human, it is suggested that the acutely uremic rat might be employed as an experimental model for further elucidating the underlying mechanisms of glucose intolerance in uremia.

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The effects of acute uremia on plasma glucose, insulin and growth hormone in the rat

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