The effects of acute uremia on plasma glucose, insulin and growth hormone in the rat

M. Nitzan*, B. E. Metzger, J. F. Wilber

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The effects of acute uremic syndrome upon plasma glucose, insulin and growth hormone were evaluated in the fasted rat 24 hours following bilateral nephrectomy. Appropriate control studies were instituted to correct for the non-specific effects of surgical intervention. The mean levels of plasma glucose, IRI and GH, as well as insulin to glucose ratio were significantly higher in the uremic animals than in the sham-operated controls. The fasting hyperglycemia in the presence of high levels of circulating IRI observed in the nephrectomized rats suggest impaired responsiveness of the peripheral tissues to the action of insulin. Since similar findings have been reported in chronic renal failure in the human, it is suggested that the acutely uremic rat might be employed as an experimental model for further elucidating the underlying mechanisms of glucose intolerance in uremia.

Original languageEnglish (US)
Pages (from-to)671-676
Number of pages6
JournalLife Sciences
Issue number12 PART 2
StatePublished - Jun 22 1971

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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