The effects of cinacalcet in older and younger patients on hemodialysis

The evaluation of cinacalcet HCL therapy to lower cardiovascular events (EVOLVE) trial

Patrick S. Parfrey*, Tilman B. Drüeke, Geoffrey A. Block, Ricardo Correa-Rotter, Jürgen Floege, Charles A. Herzog, Gerard M. London, Kenneth W. Mahaffey, Sharon M. Moe, David C. Wheeler, Yumi Kubo, Bastian Dehmel, William G. Goodman, Glenn M. Chertow, J. Santos, C. Najun Zarazaga, I. Marin, N. Garrote, A. Cusumano, N. Peñalba & 569 others E. Del Valle, L. Juncos, J. Martinez Saye, L. Lef, V. Altobelli, G. Petraglia, G. Rosa Diez, W. Douthat, J. Lobo, C. Gallart, A. Lafalla, G. Diez, B. Linares, N. Lopez, N. Ramirez, R. Gonzalez, R. Valtuille, H. Beresan, O. Hermida, G. Rudolf, N. Marchetta, M. Rano, M. Ramirez, N. García, A. Gillies, B. Jones, E. Pedagogos, R. Walker, G. Talaulikar, K. Bannister, M. Suranyi, A. Kark, S. Roger, P. Kerr, A. Disney, P. Mount, M. Fraenkel, M. Mathew, R. Fassett, M. Jose, C. Hawley, M. Lonergan, J. Mackie, P. Ferrari, S. Menahem, J. Sabto, B. Hutchison, R. Langham, C. Pollock, H. Holzer, R. Oberbauer, I. Arias, H. Graf, G. Mayer, K. Lhotta, U. Neyer, R. Klauser, W. Hoerl, S. Horn, J. Kovarik, R. Kramar, M. Eigner, M. Dhaene, J. Billiouw, J. De Meester, X. Warling, P. Cambier-Dwelschauwers, P. Evenepoel, R. Daelemans, M. Dratwa, B. Maes, J. Stolear, T. Dejagere, J. Vanwalleghem, K. Bouman, M. Jadoul, J. Peeters, R. Vanholder, C. Tielemans, J. Donck, F. Almeida, J. Picollo de Oliveira, E. Burdmann, V. Garcia, F. Saldanha Thome, L. Deboni, R. Bregman, J. Lugon, S. Araújo, S. Ferreira Filho, E. de Francesco Daher, M. Sperto Baptista, A. Carvalho, D. d’Avila, M. Moyses Neto, L. Yu, M. Bastos, P. Sampaio Lacativa, V. Jorgetti, E. de Almeida Romão, J. Cardeal da Costa, R. Pecoits Filho, P. Gordan, N. Salgado, M. Teixeira Araújo, S. Neiva Coelho, I. Oliveira, R. Moysés, L. Vasconcellos, P. Batista, J. Luiz Gross, A. Pedrosa, S. Cournoyer, M. LeBlanc, S. Chow, S. Karunakaran, G. Wong, S. Tobe, S. Desmeules, D. Zimmerman, S. Murphy, P. Montambault, S. Donnelly, J. MacRae, B. Culleton, S. Soroka, C. Rabbat, K. Jindal, M. Vasilevsky, M. Michaud, E. Wijeyesinghe, J. Zacharias, C. Lok, N. Muirhead, M. Verrelli, G. Da Roza, D. Sapir, K. Olgaard, H. Daugaard, L. Brandi, P. Jensen, H. Boulechfar, K. Ang, P. Simon, P. Rieu, P. Brunet, G. Touchard, G. London, P. Urena Torres, C. Combe, A. Durrbach, J. Ortiz, T. Hannedouche, C. Vela, A. Lionet, P. Ryckelynck, P. Zaoui, G. Choukroun, H. Fessi, P. Lang, P. Stroumza, D. Joly, C. Mousson, M. Laville, F. Dellanna, C. Erley, J. Braun, M. Rambausek, W. Riegel, M. Klingberg, E. Schwertfeger, V. Wizemann, K. Eckardt, H. Reichel, J. Floege, J. Passauer, E. Hübel, N. Frischmuth, R. Liebl, R. Fiedler, V. Schwenger, A. Voßkühler, U. Kunzendorf, L. Renders, D. Rattensberger, L. Rump, M. Ketteler, H. Neumayer, F. Zantvoort, R. Stahl, E. Ladanyi, I. Kulcsar, I. Mezei, B. Csiky, C. Rikker, O. Arkossy, K. Berta, J. Szegedi, L. Major, S. Ferenczi, A. Fekete, T. Szabo, G. Zakar, G. Wagner, S. Kazup Erdelyine, B. Borbas, J. Eustace, D. Reddan, G. Capasso, F. Locatelli, G. Villa, M. Cozzolino, D. Brancaccio, P. Messa, P. Bolasco, B. Ricciardi, F. Malberti, E. Moriero, G. Cannella, V. Ortalda, S. Stefoni, G. Frascà, G. Cappelli, A. Albertazzi, C. Zoccali, M. Farina, A. Elli, F. Avella, P. Ondei, G. Mingardi, R. Errico, A. Losito, S. Di Giulio, G. Pertosa, F. Schena, G. Grandaliano, L. Gesualdo, M. Auricchio, T. Bochicchio-Ricardelli, R. Correa-Rotter, F. Aranda Verástegui, J. Peña, A. Chew Wong, J. Cruz-Valdez, M. Torres Zamora, M. Solis, M. Sebastian Diaz, M. Vital Flores, E. Alvarez Sandoval, M. van den Dorpel, H. Brink, W. Van Kuijk, C. Vermeij, P. Smak Gregoor, E. Hagen, F. van der Sande, M. Klinger, M. Nowicki, M. Muszytowski, K. Bidas, W. Bentkowski, A. Wiecek, A. Ksiazek, K. Marczewski, M. Ostrowski, M. Switalski, W. Sulowicz, J. Matuszkiewicz-Rowinska, M. Mysliwiec, M. Durlik, B. Rutkowski, F. Macario, B. Carvalho, J. Frazao, D. Machado, A. Weigert, A. Andrusev, O. Khrustalev, A. Zemtchenkov, K. Gurevich, K. Staroselsky, N. Khadikova, L. Rozhinskaya, G. Timokhovskaya, A. Strokov, O. Balkarova, V. Ermolenko, E. Kolmakova, M. Komandenko, M. Timofeev, V. Shilo, G. Shostka, A. Smirnov, V. Anashkin, G. Volgina, O. Domashenko, A. Gurevich, D. Perlin, J. Martínez García, E. Andrés Ribes, E. Coll Piera, M. Fernandez Lucas, M. Galicia, M. Prados, M. González, R. Romero, de Francisco Martín de Francisco, J. Montenegro, C. Santiago, F. García, J. Alcázar de La Ossa, J. Arrieta, J. Pons, A. Martín-Malo, J. Soler Amigó, A. Cases, G. Sterner, G. Jensen, B. Wikström, S. Jacobson, U. Lund, L. Weiss, A. Ståhl, B. von Albertini, M. Burnier, P. Meier, P. Martin, D. Uehlinger, M. Dickenmann, M. Yaqoob, D. Zehnder, P. Kalra, D. Wheeler, N. Padmanabhan, S. Roe, D. Eadington, N. Pritchard, A. Hutchison, S. Davies, M. Wilkie, M. Davies, P. Pai, P. Swift, J. Kwan, D. Goldsmith, C. Tomson, J. Stratton, I. Dasgupta, S. Sarkar, M. Moustafa, K. Gandhi, A. Jamal, E. Galindo-Ramos, J. Tuazon, D. Batlle, K. Tucker, B. Schiller-Moran, A. Assefi, C. Martinez, L. Samuels, J. Goldman, J. Cangiano-Rivera, R. Darwish, M. Lee, J. Topf, K. Kapatkin, H. Baer, R. Kopelman, M. Acharya, D. Tharpe, M. Bernardo, P. Nader, J. Guzman-Rivera, P. Pergola, M. Sekkarie, E. Alas, P. Zager, K. Liss, J. Navarro, M. Roppolo, C. Denu-Ciocca, A. Kshirsagar, M. El Khatib, K. Kant, D. Scott, B. Murthyr, F. Finkelstein, G. Keightley, R. McCrary, J. Pitone, T. Cavalieri, A. Tsang, B. Pellegrino, R. Schmidt, S. Ahmad, C. Brown, E. Friedman, N. Mittman, S. Fadem, W. Shapiro, M. Reddy, S. Goldberger, Y. Woredekal, A. Agarwal, M. Anger, M. Haque, P. Chidester, R. Kohli, S. Rubinstein, G. Newman, R. Gladish, O. Ayodeji, S. Soman, S. Sprague, N. Hunt, T. Gehr, D. Rizk, D. Warnock, D. Polack, M. Pahl, D. Fischer, P. Dreyer, G. James, F. Husserl, T. Rogers, A. Raff, J. Sedor, M. Silver, M. Smith, S. Steinberg, T. DelGiorno, E. Jones, P. D. Cunha, J. Cheng, V. Pogue, G. Block, S. Blumenthal, E. Brown, C. Charytan, J. Buerkert, M. Cook, A. Felsenfeld, N. Tareen, A. Gupta, T. Herman, S. Diamond, C. Hura, M. Laski, J. MacLaurin, T. Plumb, G. Brosnahan, J. Kumar, M. Henriquez, C. Poole, E. Osanloo, A. Matalon, C. Sholer, S. Arfeen, M. Azer, M. Belledonne, M. Gross, E. Dunnigan, K. McConnell, B. Becker, F. Skinner, R. Rigolosi, D. Spiegel, M. Stegman, R. Patak, D. Streja, U. Ranjit, T. Youell, T. Wooldridge, C. Stafford, R. Cottiero, M. Weinberg, M. Schonefeld, E. Shahmir, A. Hazzan, A. Ashfaq, K. Bhandari, W. Cleveland, M. Culpepper, J. Golden, L. Lai, Y. Lien, V. Lorica, J. Robertson, K. Malireddi, S. Morse, V. Thakur, A. Israelit, P. Raguram, H. Alfred, W. Weise, F. Al-Saghir, M. El Shahawy, A. Rastogi, A. Nissenson, N. Kopyt, R. Lynn, J. Lea, W. McClellan, P. Teredesai, S. Ong, S. Tolkan, J. Sugihara, T. Minga, R. Mehrotra, R. Minasian, D. Bhatia, R. Specter, J. Capelli, P. Sidhu, S. Dalal, P. Dykes, M. Khan, F. Rahim, M. Saklayen, A. Thomas, B. Michael, M. Torres, H. Al-Bander, B. Murray, A. Abukurah, B. Gupta, S. Nosrati, R. Raja, S. Zeig, M. Braun, A. Amatya, J. Endsley, Z. Sharon, A. Gupta, G. Dolson, F. Dumler, K. Ntoso, S. Rosansky, N. Kumar, V. Gura, N. Thompson, D. Goldfarb, R. Halligan, J. Middleton, A. Widerhorn, L. Arbeit, J. Arruda, T. Crouch, L. Friedman, S. Khokhar, J. Mittleman, P. Light, B. Taparia, C. West, J. Cotton, R. Dhingra, L. Kleinman, F. Arif, S. Lew, T. Nammour, J. Sterrett, M. Williams, J. Ramirez, J. Rubin, J. McCarthy, S. Noble, M. Chaffin, A. Rekhi, of Cinacalcet HCL Therapy to Lower Cardiovascular Events (EVOLVE) Trial Investigators Evaluation of Cinacalcet HCL Therapy to Lower Cardiovascular Events (EVOLVE) Trial Investigators

*Corresponding author for this work

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background and objectives The calcimimetic cinacalcet reduced the risk of death or cardiovascular (CV) events in older, but not younger, patients with moderate to severe secondary hyperparathyroidism (HPT) who were receiving hemodialysis. To determine whether the lower risk in younger patients might be due to lower baseline CV risk and more frequent use of cointerventions that reduce parathyroid hormone (kidney transplantation, parathyroidectomy, and commercial cinacalcet use), this study examined the effects of cinacalcet in older (≥ 65 years, n=1005) and younger (<65 years, n=2878) patients. Design, setting, participants, & measurements Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) was a global, multicenter, randomized placebo-controlled trial in 3883 prevalent patients on hemodialysis, whose outcomes included death, major CV events, and development of severe unremitting HPT. The age subgroup analysis was prespecified. ResultsOlder patients had higher baseline prevalence of diabetesmellitus and CV comorbidity. Annualized rates of kidney transplantation and parathyroidectomy were > 3-fold higher in younger relative to older patients and were more frequent in patients randomized to placebo. In older patients, the adjusted relative hazard (95% confidence interval) for the primary composite (CV) end point (cinacalcet versus placebo) was 0.70 (0.60 to 0.81); in younger patients, the relative hazard was 0.97 (0.86 to 1.09). Corresponding adjusted relative hazards for mortality were 0.68 (0.51 to 0.81) and 0.99 (0.86 to 1.13). Reduction in the risk of severe unremitting HPT was similar in both groups. Conclusions In the EVOLVE trial, cinacalcet decreased the risk of death and of major CV events in older, but not younger, patients with moderate to severe HPT who were receiving hemodialysis. Effect modification by age may be partly explained by differences in underlying CV risk and differential application of cointerventions that reduce parathyroid hormone.

Original languageEnglish (US)
Pages (from-to)791-799
Number of pages9
JournalClinical Journal of the American Society of Nephrology
Volume10
Issue number5
DOIs
StatePublished - Jan 1 2015

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Renal Dialysis
Hyperparathyroidism
Parathyroid Hormone
Therapeutics
Placebos
Parathyroidectomy
Secondary Hyperparathyroidism
Risk Reduction Behavior
Cinacalcet Hydrochloride
Kidney Transplantation
Confidence Intervals
Mortality

ASJC Scopus subject areas

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation

Cite this

Parfrey, P. S., Drüeke, T. B., Block, G. A., Correa-Rotter, R., Floege, J., Herzog, C. A., ... Evaluation of Cinacalcet HCL Therapy to Lower Cardiovascular Events (EVOLVE) Trial Investigators, O. C. HCL. T. T. L. C. E. EVOLVE. T. I. (2015). The effects of cinacalcet in older and younger patients on hemodialysis: The evaluation of cinacalcet HCL therapy to lower cardiovascular events (EVOLVE) trial. Clinical Journal of the American Society of Nephrology, 10(5), 791-799. https://doi.org/10.2215/CJN.07730814
Parfrey, Patrick S. ; Drüeke, Tilman B. ; Block, Geoffrey A. ; Correa-Rotter, Ricardo ; Floege, Jürgen ; Herzog, Charles A. ; London, Gerard M. ; Mahaffey, Kenneth W. ; Moe, Sharon M. ; Wheeler, David C. ; Kubo, Yumi ; Dehmel, Bastian ; Goodman, William G. ; Chertow, Glenn M. ; Santos, J. ; Najun Zarazaga, C. ; Marin, I. ; Garrote, N. ; Cusumano, A. ; Peñalba, N. ; Del Valle, E. ; Juncos, L. ; Martinez Saye, J. ; Lef, L. ; Altobelli, V. ; Petraglia, G. ; Rosa Diez, G. ; Douthat, W. ; Lobo, J. ; Gallart, C. ; Lafalla, A. ; Diez, G. ; Linares, B. ; Lopez, N. ; Ramirez, N. ; Gonzalez, R. ; Valtuille, R. ; Beresan, H. ; Hermida, O. ; Rudolf, G. ; Marchetta, N. ; Rano, M. ; Ramirez, M. ; García, N. ; Gillies, A. ; Jones, B. ; Pedagogos, E. ; Walker, R. ; Talaulikar, G. ; Bannister, K. ; Suranyi, M. ; Kark, A. ; Roger, S. ; Kerr, P. ; Disney, A. ; Mount, P. ; Fraenkel, M. ; Mathew, M. ; Fassett, R. ; Jose, M. ; Hawley, C. ; Lonergan, M. ; Mackie, J. ; Ferrari, P. ; Menahem, S. ; Sabto, J. ; Hutchison, B. ; Langham, R. ; Pollock, C. ; Holzer, H. ; Oberbauer, R. ; Arias, I. ; Graf, H. ; Mayer, G. ; Lhotta, K. ; Neyer, U. ; Klauser, R. ; Hoerl, W. ; Horn, S. ; Kovarik, J. ; Kramar, R. ; Eigner, M. ; Dhaene, M. ; Billiouw, J. ; De Meester, J. ; Warling, X. ; Cambier-Dwelschauwers, P. ; Evenepoel, P. ; Daelemans, R. ; Dratwa, M. ; Maes, B. ; Stolear, J. ; Dejagere, T. ; Vanwalleghem, J. ; Bouman, K. ; Jadoul, M. ; Peeters, J. ; Vanholder, R. ; Tielemans, C. ; Donck, J. ; Almeida, F. ; Picollo de Oliveira, J. ; Burdmann, E. ; Garcia, V. ; Saldanha Thome, F. ; Deboni, L. ; Bregman, R. ; Lugon, J. ; Araújo, S. ; Ferreira Filho, S. ; de Francesco Daher, E. ; Sperto Baptista, M. ; Carvalho, A. ; d’Avila, D. ; Moyses Neto, M. ; Yu, L. ; Bastos, M. ; Sampaio Lacativa, P. ; Jorgetti, V. ; de Almeida Romão, E. ; Cardeal da Costa, J. ; Pecoits Filho, R. ; Gordan, P. ; Salgado, N. ; Teixeira Araújo, M. ; Neiva Coelho, S. ; Oliveira, I. ; Moysés, R. ; Vasconcellos, L. ; Batista, P. ; Luiz Gross, J. ; Pedrosa, A. ; Cournoyer, S. ; LeBlanc, M. ; Chow, S. ; Karunakaran, S. ; Wong, G. ; Tobe, S. ; Desmeules, S. ; Zimmerman, D. ; Murphy, S. ; Montambault, P. ; Donnelly, S. ; MacRae, J. ; Culleton, B. ; Soroka, S. ; Rabbat, C. ; Jindal, K. ; Vasilevsky, M. ; Michaud, M. ; Wijeyesinghe, E. ; Zacharias, J. ; Lok, C. ; Muirhead, N. ; Verrelli, M. ; Da Roza, G. ; Sapir, D. ; Olgaard, K. ; Daugaard, H. ; Brandi, L. ; Jensen, P. ; Boulechfar, H. ; Ang, K. ; Simon, P. ; Rieu, P. ; Brunet, P. ; Touchard, G. ; London, G. ; Urena Torres, P. ; Combe, C. ; Durrbach, A. ; Ortiz, J. ; Hannedouche, T. ; Vela, C. ; Lionet, A. ; Ryckelynck, P. ; Zaoui, P. ; Choukroun, G. ; Fessi, H. ; Lang, P. ; Stroumza, P. ; Joly, D. ; Mousson, C. ; Laville, M. ; Dellanna, F. ; Erley, C. ; Braun, J. ; Rambausek, M. ; Riegel, W. ; Klingberg, M. ; Schwertfeger, E. ; Wizemann, V. ; Eckardt, K. ; Reichel, H. ; Floege, J. ; Passauer, J. ; Hübel, E. ; Frischmuth, N. ; Liebl, R. ; Fiedler, R. ; Schwenger, V. ; Voßkühler, A. ; Kunzendorf, U. ; Renders, L. ; Rattensberger, D. ; Rump, L. ; Ketteler, M. ; Neumayer, H. ; Zantvoort, F. ; Stahl, R. ; Ladanyi, E. ; Kulcsar, I. ; Mezei, I. ; Csiky, B. ; Rikker, C. ; Arkossy, O. ; Berta, K. ; Szegedi, J. ; Major, L. ; Ferenczi, S. ; Fekete, A. ; Szabo, T. ; Zakar, G. ; Wagner, G. ; Kazup Erdelyine, S. ; Borbas, B. ; Eustace, J. ; Reddan, D. ; Capasso, G. ; Locatelli, F. ; Villa, G. ; Cozzolino, M. ; Brancaccio, D. ; Messa, P. ; Bolasco, P. ; Ricciardi, B. ; Malberti, F. ; Moriero, E. ; Cannella, G. ; Ortalda, V. ; Stefoni, S. ; Frascà, G. ; Cappelli, G. ; Albertazzi, A. ; Zoccali, C. ; Farina, M. ; Elli, A. ; Avella, F. ; Ondei, P. ; Mingardi, G. ; Errico, R. ; Losito, A. ; Di Giulio, S. ; Pertosa, G. ; Schena, F. ; Grandaliano, G. ; Gesualdo, L. ; Auricchio, M. ; Bochicchio-Ricardelli, T. ; Correa-Rotter, R. ; Aranda Verástegui, F. ; Peña, J. ; Chew Wong, A. ; Cruz-Valdez, J. ; Torres Zamora, M. ; Solis, M. ; Sebastian Diaz, M. ; Vital Flores, M. ; Alvarez Sandoval, E. ; van den Dorpel, M. ; Brink, H. ; Van Kuijk, W. ; Vermeij, C. ; Smak Gregoor, P. ; Hagen, E. ; van der Sande, F. ; Klinger, M. ; Nowicki, M. ; Muszytowski, M. ; Bidas, K. ; Bentkowski, W. ; Wiecek, A. ; Ksiazek, A. ; Marczewski, K. ; Ostrowski, M. ; Switalski, M. ; Sulowicz, W. ; Matuszkiewicz-Rowinska, J. ; Mysliwiec, M. ; Durlik, M. ; Rutkowski, B. ; Macario, F. ; Carvalho, B. ; Frazao, J. ; Machado, D. ; Weigert, A. ; Andrusev, A. ; Khrustalev, O. ; Zemtchenkov, A. ; Gurevich, K. ; Staroselsky, K. ; Khadikova, N. ; Rozhinskaya, L. ; Timokhovskaya, G. ; Strokov, A. ; Balkarova, O. ; Ermolenko, V. ; Kolmakova, E. ; Komandenko, M. ; Timofeev, M. ; Shilo, V. ; Shostka, G. ; Smirnov, A. ; Anashkin, V. ; Volgina, G. ; Domashenko, O. ; Gurevich, A. ; Perlin, D. ; Martínez García, J. ; Andrés Ribes, E. ; Coll Piera, E. ; Fernandez Lucas, M. ; Galicia, M. ; Prados, M. ; González, M. ; Romero, R. ; Martín de Francisco, de Francisco ; Montenegro, J. ; Santiago, C. ; García, F. ; Alcázar de La Ossa, J. ; Arrieta, J. ; Pons, J. ; Martín-Malo, A. ; Soler Amigó, J. ; Cases, A. ; Sterner, G. ; Jensen, G. ; Wikström, B. ; Jacobson, S. ; Lund, U. ; Weiss, L. ; Ståhl, A. ; von Albertini, B. ; Burnier, M. ; Meier, P. ; Martin, P. ; Uehlinger, D. ; Dickenmann, M. ; Yaqoob, M. ; Zehnder, D. ; Kalra, P. ; Wheeler, D. ; Padmanabhan, N. ; Roe, S. ; Eadington, D. ; Pritchard, N. ; Hutchison, A. ; Davies, S. ; Wilkie, M. ; Davies, M. ; Pai, P. ; Swift, P. ; Kwan, J. ; Goldsmith, D. ; Tomson, C. ; Stratton, J. ; Dasgupta, I. ; Sarkar, S. ; Moustafa, M. ; Gandhi, K. ; Jamal, A. ; Galindo-Ramos, E. ; Tuazon, J. ; Batlle, D. ; Tucker, K. ; Schiller-Moran, B. ; Assefi, A. ; Martinez, C. ; Samuels, L. ; Goldman, J. ; Cangiano-Rivera, J. ; Darwish, R. ; Lee, M. ; Topf, J. ; Kapatkin, K. ; Baer, H. ; Kopelman, R. ; Acharya, M. ; Tharpe, D. ; Bernardo, M. ; Nader, P. ; Guzman-Rivera, J. ; Pergola, P. ; Sekkarie, M. ; Alas, E. ; Zager, P. ; Liss, K. ; Navarro, J. ; Roppolo, M. ; Denu-Ciocca, C. ; Kshirsagar, A. ; El Khatib, M. ; Kant, K. ; Scott, D. ; Murthyr, B. ; Finkelstein, F. ; Keightley, G. ; McCrary, R. ; Pitone, J. ; Cavalieri, T. ; Tsang, A. ; Pellegrino, B. ; Schmidt, R. ; Ahmad, S. ; Brown, C. ; Friedman, E. ; Mittman, N. ; Fadem, S. ; Shapiro, W. ; Reddy, M. ; Goldberger, S. ; Woredekal, Y. ; Agarwal, A. ; Anger, M. ; Haque, M. ; Chidester, P. ; Kohli, R. ; Rubinstein, S. ; Newman, G. ; Gladish, R. ; Ayodeji, O. ; Soman, S. ; Sprague, S. ; Hunt, N. ; Gehr, T. ; Rizk, D. ; Warnock, D. ; Polack, D. ; Pahl, M. ; Fischer, D. ; Dreyer, P. ; James, G. ; Husserl, F. ; Rogers, T. ; Raff, A. ; Sedor, J. ; Silver, M. ; Smith, M. ; Steinberg, S. ; DelGiorno, T. ; Jones, E. ; Cunha, P. D. ; Cheng, J. ; Pogue, V. ; Block, G. ; Blumenthal, S. ; Brown, E. ; Charytan, C. ; Buerkert, J. ; Cook, M. ; Felsenfeld, A. ; Tareen, N. ; Gupta, A. ; Herman, T. ; Diamond, S. ; Hura, C. ; Laski, M. ; MacLaurin, J. ; Plumb, T. ; Brosnahan, G. ; Kumar, J. ; Henriquez, M. ; Poole, C. ; Osanloo, E. ; Matalon, A. ; Sholer, C. ; Arfeen, S. ; Azer, M. ; Belledonne, M. ; Gross, M. ; Dunnigan, E. ; McConnell, K. ; Becker, B. ; Skinner, F. ; Rigolosi, R. ; Spiegel, D. ; Stegman, M. ; Patak, R. ; Streja, D. ; Ranjit, U. ; Youell, T. ; Wooldridge, T. ; Stafford, C. ; Cottiero, R. ; Weinberg, M. ; Schonefeld, M. ; Shahmir, E. ; Hazzan, A. ; Ashfaq, A. ; Bhandari, K. ; Cleveland, W. ; Culpepper, M. ; Golden, J. ; Lai, L. ; Lien, Y. ; Lorica, V. ; Robertson, J. ; Malireddi, K. ; Morse, S. ; Thakur, V. ; Israelit, A. ; Raguram, P. ; Alfred, H. ; Weise, W. ; Al-Saghir, F. ; El Shahawy, M. ; Rastogi, A. ; Nissenson, A. ; Kopyt, N. ; Lynn, R. ; Lea, J. ; McClellan, W. ; Teredesai, P. ; Ong, S. ; Tolkan, S. ; Sugihara, J. ; Minga, T. ; Mehrotra, R. ; Minasian, R. ; Bhatia, D. ; Specter, R. ; Capelli, J. ; Sidhu, P. ; Dalal, S. ; Dykes, P. ; Khan, M. ; Rahim, F. ; Saklayen, M. ; Thomas, A. ; Michael, B. ; Torres, M. ; Al-Bander, H. ; Murray, B. ; Abukurah, A. ; Gupta, B. ; Nosrati, S. ; Raja, R. ; Zeig, S. ; Braun, M. ; Amatya, A. ; Endsley, J. ; Sharon, Z. ; Gupta, A. ; Dolson, G. ; Dumler, F. ; Ntoso, K. ; Rosansky, S. ; Kumar, N. ; Gura, V. ; Thompson, N. ; Goldfarb, D. ; Halligan, R. ; Middleton, J. ; Widerhorn, A. ; Arbeit, L. ; Arruda, J. ; Crouch, T. ; Friedman, L. ; Khokhar, S. ; Mittleman, J. ; Light, P. ; Taparia, B. ; West, C. ; Cotton, J. ; Dhingra, R. ; Kleinman, L. ; Arif, F. ; Lew, S. ; Nammour, T. ; Sterrett, J. ; Williams, M. ; Ramirez, J. ; Rubin, J. ; McCarthy, J. ; Noble, S. ; Chaffin, M. ; Rekhi, A. ; Evaluation of Cinacalcet HCL Therapy to Lower Cardiovascular Events (EVOLVE) Trial Investigators, of Cinacalcet HCL Therapy to Lower Cardiovascular Events (EVOLVE) Trial Investigators. / The effects of cinacalcet in older and younger patients on hemodialysis : The evaluation of cinacalcet HCL therapy to lower cardiovascular events (EVOLVE) trial. In: Clinical Journal of the American Society of Nephrology. 2015 ; Vol. 10, No. 5. pp. 791-799.
@article{33c92dd5757e46229b34535979c76d52,
title = "The effects of cinacalcet in older and younger patients on hemodialysis: The evaluation of cinacalcet HCL therapy to lower cardiovascular events (EVOLVE) trial",
abstract = "Background and objectives The calcimimetic cinacalcet reduced the risk of death or cardiovascular (CV) events in older, but not younger, patients with moderate to severe secondary hyperparathyroidism (HPT) who were receiving hemodialysis. To determine whether the lower risk in younger patients might be due to lower baseline CV risk and more frequent use of cointerventions that reduce parathyroid hormone (kidney transplantation, parathyroidectomy, and commercial cinacalcet use), this study examined the effects of cinacalcet in older (≥ 65 years, n=1005) and younger (<65 years, n=2878) patients. Design, setting, participants, & measurements Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) was a global, multicenter, randomized placebo-controlled trial in 3883 prevalent patients on hemodialysis, whose outcomes included death, major CV events, and development of severe unremitting HPT. The age subgroup analysis was prespecified. ResultsOlder patients had higher baseline prevalence of diabetesmellitus and CV comorbidity. Annualized rates of kidney transplantation and parathyroidectomy were > 3-fold higher in younger relative to older patients and were more frequent in patients randomized to placebo. In older patients, the adjusted relative hazard (95{\%} confidence interval) for the primary composite (CV) end point (cinacalcet versus placebo) was 0.70 (0.60 to 0.81); in younger patients, the relative hazard was 0.97 (0.86 to 1.09). Corresponding adjusted relative hazards for mortality were 0.68 (0.51 to 0.81) and 0.99 (0.86 to 1.13). Reduction in the risk of severe unremitting HPT was similar in both groups. Conclusions In the EVOLVE trial, cinacalcet decreased the risk of death and of major CV events in older, but not younger, patients with moderate to severe HPT who were receiving hemodialysis. Effect modification by age may be partly explained by differences in underlying CV risk and differential application of cointerventions that reduce parathyroid hormone.",
author = "Parfrey, {Patrick S.} and Dr{\"u}eke, {Tilman B.} and Block, {Geoffrey A.} and Ricardo Correa-Rotter and J{\"u}rgen Floege and Herzog, {Charles A.} and London, {Gerard M.} and Mahaffey, {Kenneth W.} and Moe, {Sharon M.} and Wheeler, {David C.} and Yumi Kubo and Bastian Dehmel and Goodman, {William G.} and Chertow, {Glenn M.} and J. Santos and {Najun Zarazaga}, C. and I. Marin and N. Garrote and A. Cusumano and N. Pe{\~n}alba and {Del Valle}, E. and L. Juncos and {Martinez Saye}, J. and L. Lef and V. Altobelli and G. Petraglia and {Rosa Diez}, G. and W. Douthat and J. Lobo and C. Gallart and A. Lafalla and G. Diez and B. Linares and N. Lopez and N. Ramirez and R. Gonzalez and R. Valtuille and H. Beresan and O. Hermida and G. Rudolf and N. Marchetta and M. Rano and M. Ramirez and N. Garc{\'i}a and A. Gillies and B. Jones and E. Pedagogos and R. Walker and G. Talaulikar and K. Bannister and M. Suranyi and A. Kark and S. Roger and P. Kerr and A. Disney and P. Mount and M. Fraenkel and M. Mathew and R. Fassett and M. Jose and C. Hawley and M. Lonergan and J. Mackie and P. Ferrari and S. Menahem and J. Sabto and B. Hutchison and R. Langham and C. Pollock and H. Holzer and R. Oberbauer and I. Arias and H. Graf and G. Mayer and K. Lhotta and U. Neyer and R. Klauser and W. Hoerl and S. Horn and J. Kovarik and R. Kramar and M. Eigner and M. Dhaene and J. Billiouw and {De Meester}, J. and X. Warling and P. Cambier-Dwelschauwers and P. Evenepoel and R. Daelemans and M. Dratwa and B. Maes and J. Stolear and T. Dejagere and J. Vanwalleghem and K. Bouman and M. Jadoul and J. Peeters and R. Vanholder and C. Tielemans and J. Donck and F. Almeida and {Picollo de Oliveira}, J. and E. Burdmann and V. Garcia and {Saldanha Thome}, F. and L. Deboni and R. Bregman and J. Lugon and S. Ara{\'u}jo and {Ferreira Filho}, S. and {de Francesco Daher}, E. and {Sperto Baptista}, M. and A. Carvalho and D. d’Avila and {Moyses Neto}, M. and L. Yu and M. Bastos and {Sampaio Lacativa}, P. and V. Jorgetti and {de Almeida Rom{\~a}o}, E. and {Cardeal da Costa}, J. and {Pecoits Filho}, R. and P. Gordan and N. Salgado and {Teixeira Ara{\'u}jo}, M. and {Neiva Coelho}, S. and I. Oliveira and R. Moys{\'e}s and L. Vasconcellos and P. Batista and {Luiz Gross}, J. and A. Pedrosa and S. Cournoyer and M. LeBlanc and S. Chow and S. Karunakaran and G. Wong and S. Tobe and S. Desmeules and D. Zimmerman and S. Murphy and P. Montambault and S. Donnelly and J. MacRae and B. Culleton and S. Soroka and C. Rabbat and K. Jindal and M. Vasilevsky and M. Michaud and E. Wijeyesinghe and J. Zacharias and C. Lok and N. Muirhead and M. Verrelli and {Da Roza}, G. and D. Sapir and K. Olgaard and H. Daugaard and L. Brandi and P. Jensen and H. Boulechfar and K. Ang and P. Simon and P. Rieu and P. Brunet and G. Touchard and G. London and {Urena Torres}, P. and C. Combe and A. Durrbach and J. Ortiz and T. Hannedouche and C. Vela and A. Lionet and P. Ryckelynck and P. Zaoui and G. Choukroun and H. Fessi and P. Lang and P. Stroumza and D. Joly and C. Mousson and M. Laville and F. Dellanna and C. Erley and J. Braun and M. Rambausek and W. Riegel and M. Klingberg and E. Schwertfeger and V. Wizemann and K. Eckardt and H. Reichel and J. Floege and J. Passauer and E. H{\"u}bel and N. Frischmuth and R. Liebl and R. Fiedler and V. Schwenger and A. Vo{\ss}k{\"u}hler and U. Kunzendorf and L. Renders and D. Rattensberger and L. Rump and M. Ketteler and H. Neumayer and F. Zantvoort and R. Stahl and E. Ladanyi and I. Kulcsar and I. Mezei and B. Csiky and C. Rikker and O. Arkossy and K. Berta and J. Szegedi and L. Major and S. Ferenczi and A. Fekete and T. Szabo and G. Zakar and G. Wagner and {Kazup Erdelyine}, S. and B. Borbas and J. Eustace and D. Reddan and G. Capasso and F. Locatelli and G. Villa and M. Cozzolino and D. Brancaccio and P. Messa and P. Bolasco and B. Ricciardi and F. Malberti and E. Moriero and G. Cannella and V. Ortalda and S. Stefoni and G. Frasc{\`a} and G. Cappelli and A. Albertazzi and C. Zoccali and M. Farina and A. Elli and F. Avella and P. Ondei and G. Mingardi and R. Errico and A. Losito and {Di Giulio}, S. and G. Pertosa and F. Schena and G. Grandaliano and L. Gesualdo and M. Auricchio and T. Bochicchio-Ricardelli and R. Correa-Rotter and {Aranda Ver{\'a}stegui}, F. and J. Pe{\~n}a and {Chew Wong}, A. and J. Cruz-Valdez and {Torres Zamora}, M. and M. Solis and {Sebastian Diaz}, M. and {Vital Flores}, M. and {Alvarez Sandoval}, E. and {van den Dorpel}, M. and H. Brink and {Van Kuijk}, W. and C. Vermeij and {Smak Gregoor}, P. and E. Hagen and {van der Sande}, F. and M. Klinger and M. Nowicki and M. Muszytowski and K. Bidas and W. Bentkowski and A. Wiecek and A. Ksiazek and K. Marczewski and M. Ostrowski and M. Switalski and W. Sulowicz and J. Matuszkiewicz-Rowinska and M. Mysliwiec and M. Durlik and B. Rutkowski and F. Macario and B. Carvalho and J. Frazao and D. Machado and A. Weigert and A. Andrusev and O. Khrustalev and A. Zemtchenkov and K. Gurevich and K. Staroselsky and N. Khadikova and L. Rozhinskaya and G. Timokhovskaya and A. Strokov and O. Balkarova and V. Ermolenko and E. Kolmakova and M. Komandenko and M. Timofeev and V. Shilo and G. Shostka and A. Smirnov and V. Anashkin and G. Volgina and O. Domashenko and A. Gurevich and D. Perlin and {Mart{\'i}nez Garc{\'i}a}, J. and {Andr{\'e}s Ribes}, E. and {Coll Piera}, E. and {Fernandez Lucas}, M. and M. Galicia and M. Prados and M. Gonz{\'a}lez and R. Romero and {Mart{\'i}n de Francisco}, {de Francisco} and J. Montenegro and C. Santiago and F. Garc{\'i}a and {Alc{\'a}zar de La Ossa}, J. and J. Arrieta and J. Pons and A. Mart{\'i}n-Malo and {Soler Amig{\'o}}, J. and A. Cases and G. Sterner and G. Jensen and B. Wikstr{\"o}m and S. Jacobson and U. Lund and L. Weiss and A. St{\aa}hl and {von Albertini}, B. and M. Burnier and P. Meier and P. Martin and D. Uehlinger and M. Dickenmann and M. Yaqoob and D. Zehnder and P. Kalra and D. Wheeler and N. Padmanabhan and S. Roe and D. Eadington and N. Pritchard and A. Hutchison and S. Davies and M. Wilkie and M. Davies and P. Pai and P. Swift and J. Kwan and D. Goldsmith and C. Tomson and J. Stratton and I. Dasgupta and S. Sarkar and M. Moustafa and K. Gandhi and A. Jamal and E. Galindo-Ramos and J. Tuazon and D. Batlle and K. Tucker and B. Schiller-Moran and A. Assefi and C. Martinez and L. Samuels and J. Goldman and J. Cangiano-Rivera and R. Darwish and M. Lee and J. Topf and K. Kapatkin and H. Baer and R. Kopelman and M. Acharya and D. Tharpe and M. Bernardo and P. Nader and J. Guzman-Rivera and P. Pergola and M. Sekkarie and E. Alas and P. Zager and K. Liss and J. Navarro and M. Roppolo and C. Denu-Ciocca and A. Kshirsagar and {El Khatib}, M. and K. Kant and D. Scott and B. Murthyr and F. Finkelstein and G. Keightley and R. McCrary and J. Pitone and T. Cavalieri and A. Tsang and B. Pellegrino and R. Schmidt and S. Ahmad and C. Brown and E. Friedman and N. Mittman and S. Fadem and W. Shapiro and M. Reddy and S. Goldberger and Y. Woredekal and A. Agarwal and M. Anger and M. Haque and P. Chidester and R. Kohli and S. Rubinstein and G. Newman and R. Gladish and O. Ayodeji and S. Soman and S. Sprague and N. Hunt and T. Gehr and D. Rizk and D. Warnock and D. Polack and M. Pahl and D. Fischer and P. Dreyer and G. James and F. Husserl and T. Rogers and A. Raff and J. Sedor and M. Silver and M. Smith and S. Steinberg and T. DelGiorno and E. Jones and Cunha, {P. D.} and J. Cheng and V. Pogue and G. Block and S. Blumenthal and E. Brown and C. Charytan and J. Buerkert and M. Cook and A. Felsenfeld and N. Tareen and A. Gupta and T. Herman and S. Diamond and C. Hura and M. Laski and J. MacLaurin and T. Plumb and G. Brosnahan and J. Kumar and M. Henriquez and C. Poole and E. Osanloo and A. Matalon and C. Sholer and S. Arfeen and M. Azer and M. Belledonne and M. Gross and E. Dunnigan and K. McConnell and B. Becker and F. Skinner and R. Rigolosi and D. Spiegel and M. Stegman and R. Patak and D. Streja and U. Ranjit and T. Youell and T. Wooldridge and C. Stafford and R. Cottiero and M. Weinberg and M. Schonefeld and E. Shahmir and A. Hazzan and A. Ashfaq and K. Bhandari and W. Cleveland and M. Culpepper and J. Golden and L. Lai and Y. Lien and V. Lorica and J. Robertson and K. Malireddi and S. Morse and V. Thakur and A. Israelit and P. Raguram and H. Alfred and W. Weise and F. Al-Saghir and {El Shahawy}, M. and A. Rastogi and A. Nissenson and N. Kopyt and R. Lynn and J. Lea and W. McClellan and P. Teredesai and S. Ong and S. Tolkan and J. Sugihara and T. Minga and R. Mehrotra and R. Minasian and D. Bhatia and R. Specter and J. Capelli and P. Sidhu and S. Dalal and P. Dykes and M. Khan and F. Rahim and M. Saklayen and A. Thomas and B. Michael and M. Torres and H. Al-Bander and B. Murray and A. Abukurah and B. Gupta and S. Nosrati and R. Raja and S. Zeig and M. Braun and A. Amatya and J. Endsley and Z. Sharon and A. Gupta and G. Dolson and F. Dumler and K. Ntoso and S. Rosansky and N. Kumar and V. Gura and N. Thompson and D. Goldfarb and R. Halligan and J. Middleton and A. Widerhorn and L. Arbeit and J. Arruda and T. Crouch and L. Friedman and S. Khokhar and J. Mittleman and P. Light and B. Taparia and C. West and J. Cotton and R. Dhingra and L. Kleinman and F. Arif and S. Lew and T. Nammour and J. Sterrett and M. Williams and J. Ramirez and J. Rubin and J. McCarthy and S. Noble and M. Chaffin and A. Rekhi and {Evaluation of Cinacalcet HCL Therapy to Lower Cardiovascular Events (EVOLVE) Trial Investigators}, {of Cinacalcet HCL Therapy to Lower Cardiovascular Events (EVOLVE) Trial Investigators}",
year = "2015",
month = "1",
day = "1",
doi = "10.2215/CJN.07730814",
language = "English (US)",
volume = "10",
pages = "791--799",
journal = "Clinical journal of the American Society of Nephrology : CJASN",
issn = "1555-9041",
publisher = "American Society of Nephrology",
number = "5",

}

Parfrey, PS, Drüeke, TB, Block, GA, Correa-Rotter, R, Floege, J, Herzog, CA, London, GM, Mahaffey, KW, Moe, SM, Wheeler, DC, Kubo, Y, Dehmel, B, Goodman, WG, Chertow, GM, Santos, J, Najun Zarazaga, C, Marin, I, Garrote, N, Cusumano, A, Peñalba, N, Del Valle, E, Juncos, L, Martinez Saye, J, Lef, L, Altobelli, V, Petraglia, G, Rosa Diez, G, Douthat, W, Lobo, J, Gallart, C, Lafalla, A, Diez, G, Linares, B, Lopez, N, Ramirez, N, Gonzalez, R, Valtuille, R, Beresan, H, Hermida, O, Rudolf, G, Marchetta, N, Rano, M, Ramirez, M, García, N, Gillies, A, Jones, B, Pedagogos, E, Walker, R, Talaulikar, G, Bannister, K, Suranyi, M, Kark, A, Roger, S, Kerr, P, Disney, A, Mount, P, Fraenkel, M, Mathew, M, Fassett, R, Jose, M, Hawley, C, Lonergan, M, Mackie, J, Ferrari, P, Menahem, S, Sabto, J, Hutchison, B, Langham, R, Pollock, C, Holzer, H, Oberbauer, R, Arias, I, Graf, H, Mayer, G, Lhotta, K, Neyer, U, Klauser, R, Hoerl, W, Horn, S, Kovarik, J, Kramar, R, Eigner, M, Dhaene, M, Billiouw, J, De Meester, J, Warling, X, Cambier-Dwelschauwers, P, Evenepoel, P, Daelemans, R, Dratwa, M, Maes, B, Stolear, J, Dejagere, T, Vanwalleghem, J, Bouman, K, Jadoul, M, Peeters, J, Vanholder, R, Tielemans, C, Donck, J, Almeida, F, Picollo de Oliveira, J, Burdmann, E, Garcia, V, Saldanha Thome, F, Deboni, L, Bregman, R, Lugon, J, Araújo, S, Ferreira Filho, S, de Francesco Daher, E, Sperto Baptista, M, Carvalho, A, d’Avila, D, Moyses Neto, M, Yu, L, Bastos, M, Sampaio Lacativa, P, Jorgetti, V, de Almeida Romão, E, Cardeal da Costa, J, Pecoits Filho, R, Gordan, P, Salgado, N, Teixeira Araújo, M, Neiva Coelho, S, Oliveira, I, Moysés, R, Vasconcellos, L, Batista, P, Luiz Gross, J, Pedrosa, A, Cournoyer, S, LeBlanc, M, Chow, S, Karunakaran, S, Wong, G, Tobe, S, Desmeules, S, Zimmerman, D, Murphy, S, Montambault, P, Donnelly, S, MacRae, J, Culleton, B, Soroka, S, Rabbat, C, Jindal, K, Vasilevsky, M, Michaud, M, Wijeyesinghe, E, Zacharias, J, Lok, C, Muirhead, N, Verrelli, M, Da Roza, G, Sapir, D, Olgaard, K, Daugaard, H, Brandi, L, Jensen, P, Boulechfar, H, Ang, K, Simon, P, Rieu, P, Brunet, P, Touchard, G, London, G, Urena Torres, P, Combe, C, Durrbach, A, Ortiz, J, Hannedouche, T, Vela, C, Lionet, A, Ryckelynck, P, Zaoui, P, Choukroun, G, Fessi, H, Lang, P, Stroumza, P, Joly, D, Mousson, C, Laville, M, Dellanna, F, Erley, C, Braun, J, Rambausek, M, Riegel, W, Klingberg, M, Schwertfeger, E, Wizemann, V, Eckardt, K, Reichel, H, Floege, J, Passauer, J, Hübel, E, Frischmuth, N, Liebl, R, Fiedler, R, Schwenger, V, Voßkühler, A, Kunzendorf, U, Renders, L, Rattensberger, D, Rump, L, Ketteler, M, Neumayer, H, Zantvoort, F, Stahl, R, Ladanyi, E, Kulcsar, I, Mezei, I, Csiky, B, Rikker, C, Arkossy, O, Berta, K, Szegedi, J, Major, L, Ferenczi, S, Fekete, A, Szabo, T, Zakar, G, Wagner, G, Kazup Erdelyine, S, Borbas, B, Eustace, J, Reddan, D, Capasso, G, Locatelli, F, Villa, G, Cozzolino, M, Brancaccio, D, Messa, P, Bolasco, P, Ricciardi, B, Malberti, F, Moriero, E, Cannella, G, Ortalda, V, Stefoni, S, Frascà, G, Cappelli, G, Albertazzi, A, Zoccali, C, Farina, M, Elli, A, Avella, F, Ondei, P, Mingardi, G, Errico, R, Losito, A, Di Giulio, S, Pertosa, G, Schena, F, Grandaliano, G, Gesualdo, L, Auricchio, M, Bochicchio-Ricardelli, T, Correa-Rotter, R, Aranda Verástegui, F, Peña, J, Chew Wong, A, Cruz-Valdez, J, Torres Zamora, M, Solis, M, Sebastian Diaz, M, Vital Flores, M, Alvarez Sandoval, E, van den Dorpel, M, Brink, H, Van Kuijk, W, Vermeij, C, Smak Gregoor, P, Hagen, E, van der Sande, F, Klinger, M, Nowicki, M, Muszytowski, M, Bidas, K, Bentkowski, W, Wiecek, A, Ksiazek, A, Marczewski, K, Ostrowski, M, Switalski, M, Sulowicz, W, Matuszkiewicz-Rowinska, J, Mysliwiec, M, Durlik, M, Rutkowski, B, Macario, F, Carvalho, B, Frazao, J, Machado, D, Weigert, A, Andrusev, A, Khrustalev, O, Zemtchenkov, A, Gurevich, K, Staroselsky, K, Khadikova, N, Rozhinskaya, L, Timokhovskaya, G, Strokov, A, Balkarova, O, Ermolenko, V, Kolmakova, E, Komandenko, M, Timofeev, M, Shilo, V, Shostka, G, Smirnov, A, Anashkin, V, Volgina, G, Domashenko, O, Gurevich, A, Perlin, D, Martínez García, J, Andrés Ribes, E, Coll Piera, E, Fernandez Lucas, M, Galicia, M, Prados, M, González, M, Romero, R, Martín de Francisco, DF, Montenegro, J, Santiago, C, García, F, Alcázar de La Ossa, J, Arrieta, J, Pons, J, Martín-Malo, A, Soler Amigó, J, Cases, A, Sterner, G, Jensen, G, Wikström, B, Jacobson, S, Lund, U, Weiss, L, Ståhl, A, von Albertini, B, Burnier, M, Meier, P, Martin, P, Uehlinger, D, Dickenmann, M, Yaqoob, M, Zehnder, D, Kalra, P, Wheeler, D, Padmanabhan, N, Roe, S, Eadington, D, Pritchard, N, Hutchison, A, Davies, S, Wilkie, M, Davies, M, Pai, P, Swift, P, Kwan, J, Goldsmith, D, Tomson, C, Stratton, J, Dasgupta, I, Sarkar, S, Moustafa, M, Gandhi, K, Jamal, A, Galindo-Ramos, E, Tuazon, J, Batlle, D, Tucker, K, Schiller-Moran, B, Assefi, A, Martinez, C, Samuels, L, Goldman, J, Cangiano-Rivera, J, Darwish, R, Lee, M, Topf, J, Kapatkin, K, Baer, H, Kopelman, R, Acharya, M, Tharpe, D, Bernardo, M, Nader, P, Guzman-Rivera, J, Pergola, P, Sekkarie, M, Alas, E, Zager, P, Liss, K, Navarro, J, Roppolo, M, Denu-Ciocca, C, Kshirsagar, A, El Khatib, M, Kant, K, Scott, D, Murthyr, B, Finkelstein, F, Keightley, G, McCrary, R, Pitone, J, Cavalieri, T, Tsang, A, Pellegrino, B, Schmidt, R, Ahmad, S, Brown, C, Friedman, E, Mittman, N, Fadem, S, Shapiro, W, Reddy, M, Goldberger, S, Woredekal, Y, Agarwal, A, Anger, M, Haque, M, Chidester, P, Kohli, R, Rubinstein, S, Newman, G, Gladish, R, Ayodeji, O, Soman, S, Sprague, S, Hunt, N, Gehr, T, Rizk, D, Warnock, D, Polack, D, Pahl, M, Fischer, D, Dreyer, P, James, G, Husserl, F, Rogers, T, Raff, A, Sedor, J, Silver, M, Smith, M, Steinberg, S, DelGiorno, T, Jones, E, Cunha, PD, Cheng, J, Pogue, V, Block, G, Blumenthal, S, Brown, E, Charytan, C, Buerkert, J, Cook, M, Felsenfeld, A, Tareen, N, Gupta, A, Herman, T, Diamond, S, Hura, C, Laski, M, MacLaurin, J, Plumb, T, Brosnahan, G, Kumar, J, Henriquez, M, Poole, C, Osanloo, E, Matalon, A, Sholer, C, Arfeen, S, Azer, M, Belledonne, M, Gross, M, Dunnigan, E, McConnell, K, Becker, B, Skinner, F, Rigolosi, R, Spiegel, D, Stegman, M, Patak, R, Streja, D, Ranjit, U, Youell, T, Wooldridge, T, Stafford, C, Cottiero, R, Weinberg, M, Schonefeld, M, Shahmir, E, Hazzan, A, Ashfaq, A, Bhandari, K, Cleveland, W, Culpepper, M, Golden, J, Lai, L, Lien, Y, Lorica, V, Robertson, J, Malireddi, K, Morse, S, Thakur, V, Israelit, A, Raguram, P, Alfred, H, Weise, W, Al-Saghir, F, El Shahawy, M, Rastogi, A, Nissenson, A, Kopyt, N, Lynn, R, Lea, J, McClellan, W, Teredesai, P, Ong, S, Tolkan, S, Sugihara, J, Minga, T, Mehrotra, R, Minasian, R, Bhatia, D, Specter, R, Capelli, J, Sidhu, P, Dalal, S, Dykes, P, Khan, M, Rahim, F, Saklayen, M, Thomas, A, Michael, B, Torres, M, Al-Bander, H, Murray, B, Abukurah, A, Gupta, B, Nosrati, S, Raja, R, Zeig, S, Braun, M, Amatya, A, Endsley, J, Sharon, Z, Gupta, A, Dolson, G, Dumler, F, Ntoso, K, Rosansky, S, Kumar, N, Gura, V, Thompson, N, Goldfarb, D, Halligan, R, Middleton, J, Widerhorn, A, Arbeit, L, Arruda, J, Crouch, T, Friedman, L, Khokhar, S, Mittleman, J, Light, P, Taparia, B, West, C, Cotton, J, Dhingra, R, Kleinman, L, Arif, F, Lew, S, Nammour, T, Sterrett, J, Williams, M, Ramirez, J, Rubin, J, McCarthy, J, Noble, S, Chaffin, M, Rekhi, A & Evaluation of Cinacalcet HCL Therapy to Lower Cardiovascular Events (EVOLVE) Trial Investigators, OCHCLTTLCEEVOLVETI 2015, 'The effects of cinacalcet in older and younger patients on hemodialysis: The evaluation of cinacalcet HCL therapy to lower cardiovascular events (EVOLVE) trial', Clinical Journal of the American Society of Nephrology, vol. 10, no. 5, pp. 791-799. https://doi.org/10.2215/CJN.07730814

The effects of cinacalcet in older and younger patients on hemodialysis : The evaluation of cinacalcet HCL therapy to lower cardiovascular events (EVOLVE) trial. / Parfrey, Patrick S.; Drüeke, Tilman B.; Block, Geoffrey A.; Correa-Rotter, Ricardo; Floege, Jürgen; Herzog, Charles A.; London, Gerard M.; Mahaffey, Kenneth W.; Moe, Sharon M.; Wheeler, David C.; Kubo, Yumi; Dehmel, Bastian; Goodman, William G.; Chertow, Glenn M.; Santos, J.; Najun Zarazaga, C.; Marin, I.; Garrote, N.; Cusumano, A.; Peñalba, N.; Del Valle, E.; Juncos, L.; Martinez Saye, J.; Lef, L.; Altobelli, V.; Petraglia, G.; Rosa Diez, G.; Douthat, W.; Lobo, J.; Gallart, C.; Lafalla, A.; Diez, G.; Linares, B.; Lopez, N.; Ramirez, N.; Gonzalez, R.; Valtuille, R.; Beresan, H.; Hermida, O.; Rudolf, G.; Marchetta, N.; Rano, M.; Ramirez, M.; García, N.; Gillies, A.; Jones, B.; Pedagogos, E.; Walker, R.; Talaulikar, G.; Bannister, K.; Suranyi, M.; Kark, A.; Roger, S.; Kerr, P.; Disney, A.; Mount, P.; Fraenkel, M.; Mathew, M.; Fassett, R.; Jose, M.; Hawley, C.; Lonergan, M.; Mackie, J.; Ferrari, P.; Menahem, S.; Sabto, J.; Hutchison, B.; Langham, R.; Pollock, C.; Holzer, H.; Oberbauer, R.; Arias, I.; Graf, H.; Mayer, G.; Lhotta, K.; Neyer, U.; Klauser, R.; Hoerl, W.; Horn, S.; Kovarik, J.; Kramar, R.; Eigner, M.; Dhaene, M.; Billiouw, J.; De Meester, J.; Warling, X.; Cambier-Dwelschauwers, P.; Evenepoel, P.; Daelemans, R.; Dratwa, M.; Maes, B.; Stolear, J.; Dejagere, T.; Vanwalleghem, J.; Bouman, K.; Jadoul, M.; Peeters, J.; Vanholder, R.; Tielemans, C.; Donck, J.; Almeida, F.; Picollo de Oliveira, J.; Burdmann, E.; Garcia, V.; Saldanha Thome, F.; Deboni, L.; Bregman, R.; Lugon, J.; Araújo, S.; Ferreira Filho, S.; de Francesco Daher, E.; Sperto Baptista, M.; Carvalho, A.; d’Avila, D.; Moyses Neto, M.; Yu, L.; Bastos, M.; Sampaio Lacativa, P.; Jorgetti, V.; de Almeida Romão, E.; Cardeal da Costa, J.; Pecoits Filho, R.; Gordan, P.; Salgado, N.; Teixeira Araújo, M.; Neiva Coelho, S.; Oliveira, I.; Moysés, R.; Vasconcellos, L.; Batista, P.; Luiz Gross, J.; Pedrosa, A.; Cournoyer, S.; LeBlanc, M.; Chow, S.; Karunakaran, S.; Wong, G.; Tobe, S.; Desmeules, S.; Zimmerman, D.; Murphy, S.; Montambault, P.; Donnelly, S.; MacRae, J.; Culleton, B.; Soroka, S.; Rabbat, C.; Jindal, K.; Vasilevsky, M.; Michaud, M.; Wijeyesinghe, E.; Zacharias, J.; Lok, C.; Muirhead, N.; Verrelli, M.; Da Roza, G.; Sapir, D.; Olgaard, K.; Daugaard, H.; Brandi, L.; Jensen, P.; Boulechfar, H.; Ang, K.; Simon, P.; Rieu, P.; Brunet, P.; Touchard, G.; London, G.; Urena Torres, P.; Combe, C.; Durrbach, A.; Ortiz, J.; Hannedouche, T.; Vela, C.; Lionet, A.; Ryckelynck, P.; Zaoui, P.; Choukroun, G.; Fessi, H.; Lang, P.; Stroumza, P.; Joly, D.; Mousson, C.; Laville, M.; Dellanna, F.; Erley, C.; Braun, J.; Rambausek, M.; Riegel, W.; Klingberg, M.; Schwertfeger, E.; Wizemann, V.; Eckardt, K.; Reichel, H.; Floege, J.; Passauer, J.; Hübel, E.; Frischmuth, N.; Liebl, R.; Fiedler, R.; Schwenger, V.; Voßkühler, A.; Kunzendorf, U.; Renders, L.; Rattensberger, D.; Rump, L.; Ketteler, M.; Neumayer, H.; Zantvoort, F.; Stahl, R.; Ladanyi, E.; Kulcsar, I.; Mezei, I.; Csiky, B.; Rikker, C.; Arkossy, O.; Berta, K.; Szegedi, J.; Major, L.; Ferenczi, S.; Fekete, A.; Szabo, T.; Zakar, G.; Wagner, G.; Kazup Erdelyine, S.; Borbas, B.; Eustace, J.; Reddan, D.; Capasso, G.; Locatelli, F.; Villa, G.; Cozzolino, M.; Brancaccio, D.; Messa, P.; Bolasco, P.; Ricciardi, B.; Malberti, F.; Moriero, E.; Cannella, G.; Ortalda, V.; Stefoni, S.; Frascà, G.; Cappelli, G.; Albertazzi, A.; Zoccali, C.; Farina, M.; Elli, A.; Avella, F.; Ondei, P.; Mingardi, G.; Errico, R.; Losito, A.; Di Giulio, S.; Pertosa, G.; Schena, F.; Grandaliano, G.; Gesualdo, L.; Auricchio, M.; Bochicchio-Ricardelli, T.; Correa-Rotter, R.; Aranda Verástegui, F.; Peña, J.; Chew Wong, A.; Cruz-Valdez, J.; Torres Zamora, M.; Solis, M.; Sebastian Diaz, M.; Vital Flores, M.; Alvarez Sandoval, E.; van den Dorpel, M.; Brink, H.; Van Kuijk, W.; Vermeij, C.; Smak Gregoor, P.; Hagen, E.; van der Sande, F.; Klinger, M.; Nowicki, M.; Muszytowski, M.; Bidas, K.; Bentkowski, W.; Wiecek, A.; Ksiazek, A.; Marczewski, K.; Ostrowski, M.; Switalski, M.; Sulowicz, W.; Matuszkiewicz-Rowinska, J.; Mysliwiec, M.; Durlik, M.; Rutkowski, B.; Macario, F.; Carvalho, B.; Frazao, J.; Machado, D.; Weigert, A.; Andrusev, A.; Khrustalev, O.; Zemtchenkov, A.; Gurevich, K.; Staroselsky, K.; Khadikova, N.; Rozhinskaya, L.; Timokhovskaya, G.; Strokov, A.; Balkarova, O.; Ermolenko, V.; Kolmakova, E.; Komandenko, M.; Timofeev, M.; Shilo, V.; Shostka, G.; Smirnov, A.; Anashkin, V.; Volgina, G.; Domashenko, O.; Gurevich, A.; Perlin, D.; Martínez García, J.; Andrés Ribes, E.; Coll Piera, E.; Fernandez Lucas, M.; Galicia, M.; Prados, M.; González, M.; Romero, R.; Martín de Francisco, de Francisco; Montenegro, J.; Santiago, C.; García, F.; Alcázar de La Ossa, J.; Arrieta, J.; Pons, J.; Martín-Malo, A.; Soler Amigó, J.; Cases, A.; Sterner, G.; Jensen, G.; Wikström, B.; Jacobson, S.; Lund, U.; Weiss, L.; Ståhl, A.; von Albertini, B.; Burnier, M.; Meier, P.; Martin, P.; Uehlinger, D.; Dickenmann, M.; Yaqoob, M.; Zehnder, D.; Kalra, P.; Wheeler, D.; Padmanabhan, N.; Roe, S.; Eadington, D.; Pritchard, N.; Hutchison, A.; Davies, S.; Wilkie, M.; Davies, M.; Pai, P.; Swift, P.; Kwan, J.; Goldsmith, D.; Tomson, C.; Stratton, J.; Dasgupta, I.; Sarkar, S.; Moustafa, M.; Gandhi, K.; Jamal, A.; Galindo-Ramos, E.; Tuazon, J.; Batlle, D.; Tucker, K.; Schiller-Moran, B.; Assefi, A.; Martinez, C.; Samuels, L.; Goldman, J.; Cangiano-Rivera, J.; Darwish, R.; Lee, M.; Topf, J.; Kapatkin, K.; Baer, H.; Kopelman, R.; Acharya, M.; Tharpe, D.; Bernardo, M.; Nader, P.; Guzman-Rivera, J.; Pergola, P.; Sekkarie, M.; Alas, E.; Zager, P.; Liss, K.; Navarro, J.; Roppolo, M.; Denu-Ciocca, C.; Kshirsagar, A.; El Khatib, M.; Kant, K.; Scott, D.; Murthyr, B.; Finkelstein, F.; Keightley, G.; McCrary, R.; Pitone, J.; Cavalieri, T.; Tsang, A.; Pellegrino, B.; Schmidt, R.; Ahmad, S.; Brown, C.; Friedman, E.; Mittman, N.; Fadem, S.; Shapiro, W.; Reddy, M.; Goldberger, S.; Woredekal, Y.; Agarwal, A.; Anger, M.; Haque, M.; Chidester, P.; Kohli, R.; Rubinstein, S.; Newman, G.; Gladish, R.; Ayodeji, O.; Soman, S.; Sprague, S.; Hunt, N.; Gehr, T.; Rizk, D.; Warnock, D.; Polack, D.; Pahl, M.; Fischer, D.; Dreyer, P.; James, G.; Husserl, F.; Rogers, T.; Raff, A.; Sedor, J.; Silver, M.; Smith, M.; Steinberg, S.; DelGiorno, T.; Jones, E.; Cunha, P. D.; Cheng, J.; Pogue, V.; Block, G.; Blumenthal, S.; Brown, E.; Charytan, C.; Buerkert, J.; Cook, M.; Felsenfeld, A.; Tareen, N.; Gupta, A.; Herman, T.; Diamond, S.; Hura, C.; Laski, M.; MacLaurin, J.; Plumb, T.; Brosnahan, G.; Kumar, J.; Henriquez, M.; Poole, C.; Osanloo, E.; Matalon, A.; Sholer, C.; Arfeen, S.; Azer, M.; Belledonne, M.; Gross, M.; Dunnigan, E.; McConnell, K.; Becker, B.; Skinner, F.; Rigolosi, R.; Spiegel, D.; Stegman, M.; Patak, R.; Streja, D.; Ranjit, U.; Youell, T.; Wooldridge, T.; Stafford, C.; Cottiero, R.; Weinberg, M.; Schonefeld, M.; Shahmir, E.; Hazzan, A.; Ashfaq, A.; Bhandari, K.; Cleveland, W.; Culpepper, M.; Golden, J.; Lai, L.; Lien, Y.; Lorica, V.; Robertson, J.; Malireddi, K.; Morse, S.; Thakur, V.; Israelit, A.; Raguram, P.; Alfred, H.; Weise, W.; Al-Saghir, F.; El Shahawy, M.; Rastogi, A.; Nissenson, A.; Kopyt, N.; Lynn, R.; Lea, J.; McClellan, W.; Teredesai, P.; Ong, S.; Tolkan, S.; Sugihara, J.; Minga, T.; Mehrotra, R.; Minasian, R.; Bhatia, D.; Specter, R.; Capelli, J.; Sidhu, P.; Dalal, S.; Dykes, P.; Khan, M.; Rahim, F.; Saklayen, M.; Thomas, A.; Michael, B.; Torres, M.; Al-Bander, H.; Murray, B.; Abukurah, A.; Gupta, B.; Nosrati, S.; Raja, R.; Zeig, S.; Braun, M.; Amatya, A.; Endsley, J.; Sharon, Z.; Gupta, A.; Dolson, G.; Dumler, F.; Ntoso, K.; Rosansky, S.; Kumar, N.; Gura, V.; Thompson, N.; Goldfarb, D.; Halligan, R.; Middleton, J.; Widerhorn, A.; Arbeit, L.; Arruda, J.; Crouch, T.; Friedman, L.; Khokhar, S.; Mittleman, J.; Light, P.; Taparia, B.; West, C.; Cotton, J.; Dhingra, R.; Kleinman, L.; Arif, F.; Lew, S.; Nammour, T.; Sterrett, J.; Williams, M.; Ramirez, J.; Rubin, J.; McCarthy, J.; Noble, S.; Chaffin, M.; Rekhi, A.; Evaluation of Cinacalcet HCL Therapy to Lower Cardiovascular Events (EVOLVE) Trial Investigators, of Cinacalcet HCL Therapy to Lower Cardiovascular Events (EVOLVE) Trial Investigators.

In: Clinical Journal of the American Society of Nephrology, Vol. 10, No. 5, 01.01.2015, p. 791-799.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The effects of cinacalcet in older and younger patients on hemodialysis

T2 - The evaluation of cinacalcet HCL therapy to lower cardiovascular events (EVOLVE) trial

AU - Parfrey, Patrick S.

AU - Drüeke, Tilman B.

AU - Block, Geoffrey A.

AU - Correa-Rotter, Ricardo

AU - Floege, Jürgen

AU - Herzog, Charles A.

AU - London, Gerard M.

AU - Mahaffey, Kenneth W.

AU - Moe, Sharon M.

AU - Wheeler, David C.

AU - Kubo, Yumi

AU - Dehmel, Bastian

AU - Goodman, William G.

AU - Chertow, Glenn M.

AU - Santos, J.

AU - Najun Zarazaga, C.

AU - Marin, I.

AU - Garrote, N.

AU - Cusumano, A.

AU - Peñalba, N.

AU - Del Valle, E.

AU - Juncos, L.

AU - Martinez Saye, J.

AU - Lef, L.

AU - Altobelli, V.

AU - Petraglia, G.

AU - Rosa Diez, G.

AU - Douthat, W.

AU - Lobo, J.

AU - Gallart, C.

AU - Lafalla, A.

AU - Diez, G.

AU - Linares, B.

AU - Lopez, N.

AU - Ramirez, N.

AU - Gonzalez, R.

AU - Valtuille, R.

AU - Beresan, H.

AU - Hermida, O.

AU - Rudolf, G.

AU - Marchetta, N.

AU - Rano, M.

AU - Ramirez, M.

AU - García, N.

AU - Gillies, A.

AU - Jones, B.

AU - Pedagogos, E.

AU - Walker, R.

AU - Talaulikar, G.

AU - Bannister, K.

AU - Suranyi, M.

AU - Kark, A.

AU - Roger, S.

AU - Kerr, P.

AU - Disney, A.

AU - Mount, P.

AU - Fraenkel, M.

AU - Mathew, M.

AU - Fassett, R.

AU - Jose, M.

AU - Hawley, C.

AU - Lonergan, M.

AU - Mackie, J.

AU - Ferrari, P.

AU - Menahem, S.

AU - Sabto, J.

AU - Hutchison, B.

AU - Langham, R.

AU - Pollock, C.

AU - Holzer, H.

AU - Oberbauer, R.

AU - Arias, I.

AU - Graf, H.

AU - Mayer, G.

AU - Lhotta, K.

AU - Neyer, U.

AU - Klauser, R.

AU - Hoerl, W.

AU - Horn, S.

AU - Kovarik, J.

AU - Kramar, R.

AU - Eigner, M.

AU - Dhaene, M.

AU - Billiouw, J.

AU - De Meester, J.

AU - Warling, X.

AU - Cambier-Dwelschauwers, P.

AU - Evenepoel, P.

AU - Daelemans, R.

AU - Dratwa, M.

AU - Maes, B.

AU - Stolear, J.

AU - Dejagere, T.

AU - Vanwalleghem, J.

AU - Bouman, K.

AU - Jadoul, M.

AU - Peeters, J.

AU - Vanholder, R.

AU - Tielemans, C.

AU - Donck, J.

AU - Almeida, F.

AU - Picollo de Oliveira, J.

AU - Burdmann, E.

AU - Garcia, V.

AU - Saldanha Thome, F.

AU - Deboni, L.

AU - Bregman, R.

AU - Lugon, J.

AU - Araújo, S.

AU - Ferreira Filho, S.

AU - de Francesco Daher, E.

AU - Sperto Baptista, M.

AU - Carvalho, A.

AU - d’Avila, D.

AU - Moyses Neto, M.

AU - Yu, L.

AU - Bastos, M.

AU - Sampaio Lacativa, P.

AU - Jorgetti, V.

AU - de Almeida Romão, E.

AU - Cardeal da Costa, J.

AU - Pecoits Filho, R.

AU - Gordan, P.

AU - Salgado, N.

AU - Teixeira Araújo, M.

AU - Neiva Coelho, S.

AU - Oliveira, I.

AU - Moysés, R.

AU - Vasconcellos, L.

AU - Batista, P.

AU - Luiz Gross, J.

AU - Pedrosa, A.

AU - Cournoyer, S.

AU - LeBlanc, M.

AU - Chow, S.

AU - Karunakaran, S.

AU - Wong, G.

AU - Tobe, S.

AU - Desmeules, S.

AU - Zimmerman, D.

AU - Murphy, S.

AU - Montambault, P.

AU - Donnelly, S.

AU - MacRae, J.

AU - Culleton, B.

AU - Soroka, S.

AU - Rabbat, C.

AU - Jindal, K.

AU - Vasilevsky, M.

AU - Michaud, M.

AU - Wijeyesinghe, E.

AU - Zacharias, J.

AU - Lok, C.

AU - Muirhead, N.

AU - Verrelli, M.

AU - Da Roza, G.

AU - Sapir, D.

AU - Olgaard, K.

AU - Daugaard, H.

AU - Brandi, L.

AU - Jensen, P.

AU - Boulechfar, H.

AU - Ang, K.

AU - Simon, P.

AU - Rieu, P.

AU - Brunet, P.

AU - Touchard, G.

AU - London, G.

AU - Urena Torres, P.

AU - Combe, C.

AU - Durrbach, A.

AU - Ortiz, J.

AU - Hannedouche, T.

AU - Vela, C.

AU - Lionet, A.

AU - Ryckelynck, P.

AU - Zaoui, P.

AU - Choukroun, G.

AU - Fessi, H.

AU - Lang, P.

AU - Stroumza, P.

AU - Joly, D.

AU - Mousson, C.

AU - Laville, M.

AU - Dellanna, F.

AU - Erley, C.

AU - Braun, J.

AU - Rambausek, M.

AU - Riegel, W.

AU - Klingberg, M.

AU - Schwertfeger, E.

AU - Wizemann, V.

AU - Eckardt, K.

AU - Reichel, H.

AU - Floege, J.

AU - Passauer, J.

AU - Hübel, E.

AU - Frischmuth, N.

AU - Liebl, R.

AU - Fiedler, R.

AU - Schwenger, V.

AU - Voßkühler, A.

AU - Kunzendorf, U.

AU - Renders, L.

AU - Rattensberger, D.

AU - Rump, L.

AU - Ketteler, M.

AU - Neumayer, H.

AU - Zantvoort, F.

AU - Stahl, R.

AU - Ladanyi, E.

AU - Kulcsar, I.

AU - Mezei, I.

AU - Csiky, B.

AU - Rikker, C.

AU - Arkossy, O.

AU - Berta, K.

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AU - Evaluation of Cinacalcet HCL Therapy to Lower Cardiovascular Events (EVOLVE) Trial Investigators, of Cinacalcet HCL Therapy to Lower Cardiovascular Events (EVOLVE) Trial Investigators

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background and objectives The calcimimetic cinacalcet reduced the risk of death or cardiovascular (CV) events in older, but not younger, patients with moderate to severe secondary hyperparathyroidism (HPT) who were receiving hemodialysis. To determine whether the lower risk in younger patients might be due to lower baseline CV risk and more frequent use of cointerventions that reduce parathyroid hormone (kidney transplantation, parathyroidectomy, and commercial cinacalcet use), this study examined the effects of cinacalcet in older (≥ 65 years, n=1005) and younger (<65 years, n=2878) patients. Design, setting, participants, & measurements Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) was a global, multicenter, randomized placebo-controlled trial in 3883 prevalent patients on hemodialysis, whose outcomes included death, major CV events, and development of severe unremitting HPT. The age subgroup analysis was prespecified. ResultsOlder patients had higher baseline prevalence of diabetesmellitus and CV comorbidity. Annualized rates of kidney transplantation and parathyroidectomy were > 3-fold higher in younger relative to older patients and were more frequent in patients randomized to placebo. In older patients, the adjusted relative hazard (95% confidence interval) for the primary composite (CV) end point (cinacalcet versus placebo) was 0.70 (0.60 to 0.81); in younger patients, the relative hazard was 0.97 (0.86 to 1.09). Corresponding adjusted relative hazards for mortality were 0.68 (0.51 to 0.81) and 0.99 (0.86 to 1.13). Reduction in the risk of severe unremitting HPT was similar in both groups. Conclusions In the EVOLVE trial, cinacalcet decreased the risk of death and of major CV events in older, but not younger, patients with moderate to severe HPT who were receiving hemodialysis. Effect modification by age may be partly explained by differences in underlying CV risk and differential application of cointerventions that reduce parathyroid hormone.

AB - Background and objectives The calcimimetic cinacalcet reduced the risk of death or cardiovascular (CV) events in older, but not younger, patients with moderate to severe secondary hyperparathyroidism (HPT) who were receiving hemodialysis. To determine whether the lower risk in younger patients might be due to lower baseline CV risk and more frequent use of cointerventions that reduce parathyroid hormone (kidney transplantation, parathyroidectomy, and commercial cinacalcet use), this study examined the effects of cinacalcet in older (≥ 65 years, n=1005) and younger (<65 years, n=2878) patients. Design, setting, participants, & measurements Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) was a global, multicenter, randomized placebo-controlled trial in 3883 prevalent patients on hemodialysis, whose outcomes included death, major CV events, and development of severe unremitting HPT. The age subgroup analysis was prespecified. ResultsOlder patients had higher baseline prevalence of diabetesmellitus and CV comorbidity. Annualized rates of kidney transplantation and parathyroidectomy were > 3-fold higher in younger relative to older patients and were more frequent in patients randomized to placebo. In older patients, the adjusted relative hazard (95% confidence interval) for the primary composite (CV) end point (cinacalcet versus placebo) was 0.70 (0.60 to 0.81); in younger patients, the relative hazard was 0.97 (0.86 to 1.09). Corresponding adjusted relative hazards for mortality were 0.68 (0.51 to 0.81) and 0.99 (0.86 to 1.13). Reduction in the risk of severe unremitting HPT was similar in both groups. Conclusions In the EVOLVE trial, cinacalcet decreased the risk of death and of major CV events in older, but not younger, patients with moderate to severe HPT who were receiving hemodialysis. Effect modification by age may be partly explained by differences in underlying CV risk and differential application of cointerventions that reduce parathyroid hormone.

UR - http://www.scopus.com/inward/record.url?scp=84929171843&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929171843&partnerID=8YFLogxK

U2 - 10.2215/CJN.07730814

DO - 10.2215/CJN.07730814

M3 - Article

VL - 10

SP - 791

EP - 799

JO - Clinical journal of the American Society of Nephrology : CJASN

JF - Clinical journal of the American Society of Nephrology : CJASN

SN - 1555-9041

IS - 5

ER -