The effects of cytochalasin b on the microfilaments of baby hamster kidney (BHK-21) cells

Robert D. Goldman*

*Corresponding author for this work

Research output: Contribution to journalArticle

89 Scopus citations

Abstract

Attempts were made to test the motile functions of bundles of microfilaments found in baby hamster kidney (BHK-21) cells, by using cytochalasin B (CB). It was found that individual cells respond differently to the drug. These differential effects are quite obvious in both light and electron microscope preparations. Some cells contain normal bundles of microfilaments even after 24 hr in CB, and other cells form muscle-like configurations which also contain arrays of microfilaments. These varied effects suggest the existence of several types of microfilaments in BHK-21 cells, and make the interpretation of the motile role of microfilaments diffcult to eveluate at the present time.

Original languageEnglish (US)
Pages (from-to)246-254
Number of pages9
JournalJournal of Cell Biology
Volume52
Issue number2
DOIs
StatePublished - Feb 1 1972

ASJC Scopus subject areas

  • Cell Biology

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