The effects of diet on the severity of central nervous system disease: One part of lab-to-lab variability

Jane E. Libbey, Daniel J. Doty, Jordan T. Sim, Matthew F. Cusick, June L. Round, Robert S. Fujinami*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Objective: Many things can impact the reproducibility of results from laboratory to laboratory. For example, food from various sources can vary markedly in composition. We examined the effects of two different food sources, the Teklad Global Soy Protein-Free Extruded Rodent Diet (irradiated diet) and the Teklad Sterilizable Rodent Diet (autoclaved diet), on central nervous system disease. Methods: Three preclinical models for human disease: Two different experimental autoimmune encephalomyelitis models (multiple sclerosis) and the Theiler's murine encephalomyelitis virus-induced seizure model (epilepsy), were examined for the effects of two different food sources on disease. Results: We found that mice fed the irradiated diet had more severe clinical disease and enhanced seizures compared with animals provided the autoclaved diet in both experimental autoimmune encephalomyelitis models examined and in the Theiler's murine encephalomyelitis virus-induced seizure model, respectively. Conclusions: Therefore, just altering the source of food (lab chow) can have marked effects on disease severity and outcome.

Original languageEnglish (US)
Pages (from-to)877-883
Number of pages7
JournalNutrition
Volume32
Issue number7-8
DOIs
StatePublished - Jul 1 2016

Keywords

  • Diet
  • Experimental autoimmune encephalomyelitis
  • Seizures
  • Theiler's murine encephalomyelitis virus

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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