The Effects of Dual-Task Cognitive Interference and Environmental Challenges on Balance in Huntington's Disease

Nicollette L. Purcell, Jennifer G Goldman, Bichun Ouyang, Bryan Bernard, Joan A. O'Keefe*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Background: Huntington's disease (HD) is characterized by chorea, balance and gait impairments, and cognitive deficits, which increase fall risk. Dual task (DT) and environmentally challenging paradigms reflect balance related to everyday life. Furthermore, the impact of cognitive deficits on balance dysfunction and falls in HD is unknown. Objective: To determine the impact of DT interference, sensory feedback, and cognitive performance on balance and falls in HD. Methods: Seventeen participants with HD (55 ± 9.7 years) and 17 age-matched controls (56.5 ± 9.3 years) underwent quantitative balance testing with APDM inertial sensors. Postural sway was assessed during conditions of manipulated stance, vision, proprioception, and cognitive demand. The DT was a concurrent verbal fluency task. Neuropsychological assessments testing multiple cognitive domains were also administered. Results: HD participants exhibited significantly greater total sway area, jerk, and variability under single-task (ST) and DT conditions compared to controls (P = 0.0002 – < 0.0001). They also demonstrated greater DT interference with vision removed for total sway area (P = 0.01) and variability (P = 0.02). Significantly worse postural control was observed in HD with vision removed and reduced proprioception (P = 0.001 – 0.01). Decreased visuospatial performance correlated with greater total sway and jerk (P = 0.01; 0.009). No balance parameters correlated with retrospective falls in HD. Conclusions: HD participants have worse postural control under DT, limited proprioception/vision, and greater DT interference with a narrowed base and no visual input. These findings may have implications for designing motor and cognitive strategies to improve balance in HD.

Original languageEnglish (US)
Pages (from-to)202-212
Number of pages11
JournalMovement Disorders Clinical Practice
Volume6
Issue number3
DOIs
StatePublished - Mar 2019

Keywords

  • Huntington's disease
  • cognition, balance
  • inertial sensors
  • postural sway

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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