The effects of interferon-γ on the central nervous system

Brian Popko*, Joshua G. Corbin, Kristine D. Baerwald, Jeffrey Dupree, Annie M. Garcia

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

138 Scopus citations

Abstract

Interferon-gamma (IFN-γ) is a pleotropic cytokine released by T-lymphocytes and natural killer cells. Normally, these cells do not traverse the blood-brain barrier at appreciable levels and, as such, IFN-γ is generally undetectable within the central nervous system (CNS). Nevertheless, in response to CNS infections, as well as during certain disorders in which the CNS is affected, T-cell traffic across the blood-brain barrier increases considerably, thereby exposing neuronal and glial cells to the potent effects of IFN-γ. A large portion of this article is devoted to the substantial circumstantial and experimental evidence that suggests that IFN-γ plays an important role in the pathogenesis of the demyelinating disorder multiple sclerosis (MS) and its animal model experimental allergic encephalomyelitis (EAE). Moreover, the biochemical and physiological effects of IFN-γ are discussed in the context of the potential consequences of such activities on the developing and mature nervous systems.

Original languageEnglish (US)
Pages (from-to)19-35
Number of pages17
JournalMolecular Neurobiology
Volume14
Issue number1-2
DOIs
StatePublished - 1997

Keywords

  • Cytokines
  • Demyelination
  • Neural development

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

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