The effects of intrathecally administered baclofen on function in patients with spasticity

S. K. Campbell*, G. L. Almelda, R. D. Penn, D. M. Corcos

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

78 Scopus citations

Abstract

The purpose of this article is to review the literature on the effects of intrathecally administered baclofen on impairment in spasticity and muscle activation patterns, on functional limitations in mobility and self-care, and on disability in daily life roles. We found plentiful evidence of improvement in spasticity, spasm, and bladder function and some reports of improved patterns of muscle activation and kinematics of single-joint movement. Improved ability to accomplish transfers, self-care, and locomotion is less consistently studied but has also been reported in about 60% to 70% of patients. Evidence of improved quality of life is primarily anecdotal but may be found in 10% to 30% of patients. We conclude that research protocols should be developed to clarify effects on control of voluntary movement, functional limitations, and quality of life.

Original languageEnglish (US)
Pages (from-to)352-362
Number of pages11
JournalPhysical therapy
Volume75
Issue number5
DOIs
StatePublished - 1995

Keywords

  • Baclofen
  • Central nervous system
  • Pharmacology
  • Spinal cord injuries

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation

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