The effects of malnutrition on serum fibronectin and reticuloendothelial function

Nathaniel J. Soper; Jeannette A. Turner; Layton F. Rikkers

doi:10.1016/0022-4804(84)90209-9

The effects of malnutrition on serum fibronectin and reticuloendothelial function

Nathaniel J. Soper, Jeannette A. Turner, Layton F. Rikkers^*

^*Corresponding author for this work

Surgery, Gastrointestinal/Endocrinology Division

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A rat model was used to investigate the effects of starvation and protein depletion on serum fibronectin levels and reticuloendothelial function. Serum fibronectin levels decreased significantly following both test diets. The uptake of opsonin-independent test agents was minimally affected by starvation and protein depletion. Clearance of gelatinized colloidal carbon, which is dependent on circulating opsonins, was significantly reduced in the malnourished animals. This clearance defect was corrected by incubation of colloidal carbon with normal serum. These data suggest that reticuloendothelial dysfunction secondary to malnutrition is primarily mediated by a deficiency of circulating opsonins.

Original language	English (US)
Pages (from-to)	431-436
Number of pages	6
Journal	Journal of Surgical Research
Volume	37
Issue number	6
DOIs	https://doi.org/10.1016/0022-4804(84)90209-9
State	Published - Dec 1984

Funding

’ Supported by Grant GM23095 Institutes of Health, Bethesda, Md. * To whom requests for reprints should This investigation was supported by NIH Grant GM23094, Bethesda, Maryland. The authors acknowledge

ASJC Scopus subject areas

Surgery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0022-4804(84)90209-9

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title = "The effects of malnutrition on serum fibronectin and reticuloendothelial function",

abstract = "A rat model was used to investigate the effects of starvation and protein depletion on serum fibronectin levels and reticuloendothelial function. Serum fibronectin levels decreased significantly following both test diets. The uptake of opsonin-independent test agents was minimally affected by starvation and protein depletion. Clearance of gelatinized colloidal carbon, which is dependent on circulating opsonins, was significantly reduced in the malnourished animals. This clearance defect was corrected by incubation of colloidal carbon with normal serum. These data suggest that reticuloendothelial dysfunction secondary to malnutrition is primarily mediated by a deficiency of circulating opsonins.",

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AU - Turner, Jeannette A.

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N2 - A rat model was used to investigate the effects of starvation and protein depletion on serum fibronectin levels and reticuloendothelial function. Serum fibronectin levels decreased significantly following both test diets. The uptake of opsonin-independent test agents was minimally affected by starvation and protein depletion. Clearance of gelatinized colloidal carbon, which is dependent on circulating opsonins, was significantly reduced in the malnourished animals. This clearance defect was corrected by incubation of colloidal carbon with normal serum. These data suggest that reticuloendothelial dysfunction secondary to malnutrition is primarily mediated by a deficiency of circulating opsonins.

AB - A rat model was used to investigate the effects of starvation and protein depletion on serum fibronectin levels and reticuloendothelial function. Serum fibronectin levels decreased significantly following both test diets. The uptake of opsonin-independent test agents was minimally affected by starvation and protein depletion. Clearance of gelatinized colloidal carbon, which is dependent on circulating opsonins, was significantly reduced in the malnourished animals. This clearance defect was corrected by incubation of colloidal carbon with normal serum. These data suggest that reticuloendothelial dysfunction secondary to malnutrition is primarily mediated by a deficiency of circulating opsonins.

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The effects of malnutrition on serum fibronectin and reticuloendothelial function

Abstract

Funding

ASJC Scopus subject areas

UN SDGs

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