The effects of repetitive transcranial magnetic stimulation on cue-induced craving in male patients with heroin use disorder

Xiaoli Liu, Xiwen Zhao, Ting Liu, Qingming Liu, Li Tang, Hui Zhang, Wenbo Luo, Zafiris J. Daskalakis, Ti Fei Yuan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background: Craving is a central feature of addiction. Early evidence suggests that repetitive transcranial magnetic stimulation is effective in reducing cue induced craving for patients with opioid use disorder (OUD). However, trials in large populations of patients with OUDs are lacking. Methods: We randomly assigned 118 male heroin patients into three groups (i.e., 10 Hz rTMS, 1 Hz rTMS and a wait-list control group) from two addiction rehabilitation centers. rTMS was applied to the left dorsolateral prefrontal cortex (DLPFC) for 20 daily consecutive sessions. Findings: Results showed that 10 Hz rTMS and 1 Hz rTMS were both effective in reducing cue-induced craving scores in heroin users when compared to the wait list group. The treatment effects lasted for up to 60 days after rTMS treatment cessation. Interpretation: Our results suggest that rTMS applied to the DLPFC is effective in reducing craving severity in heroin use disorder patients. Our results also suggest that such treatment effects can last for up to 60 days after treatment cessation.

Original languageEnglish (US)
Article number102809
JournalEBioMedicine
Volume56
DOIs
StatePublished - Jun 2020

Keywords

  • Addiction
  • Craving
  • Heroin
  • Opioid
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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