@article{648487952c8a4256a74857bb8778954d,
title = "The effects of repetitive transcranial magnetic stimulation on cue-induced craving in male patients with heroin use disorder",
abstract = "Background: Craving is a central feature of addiction. Early evidence suggests that repetitive transcranial magnetic stimulation is effective in reducing cue induced craving for patients with opioid use disorder (OUD). However, trials in large populations of patients with OUDs are lacking. Methods: We randomly assigned 118 male heroin patients into three groups (i.e., 10 Hz rTMS, 1 Hz rTMS and a wait-list control group) from two addiction rehabilitation centers. rTMS was applied to the left dorsolateral prefrontal cortex (DLPFC) for 20 daily consecutive sessions. Findings: Results showed that 10 Hz rTMS and 1 Hz rTMS were both effective in reducing cue-induced craving scores in heroin users when compared to the wait list group. The treatment effects lasted for up to 60 days after rTMS treatment cessation. Interpretation: Our results suggest that rTMS applied to the DLPFC is effective in reducing craving severity in heroin use disorder patients. Our results also suggest that such treatment effects can last for up to 60 days after treatment cessation.",
keywords = "Addiction, Craving, Heroin, Opioid, Transcranial magnetic stimulation",
author = "Xiaoli Liu and Xiwen Zhao and Ting Liu and Qingming Liu and Li Tang and Hui Zhang and Wenbo Luo and Daskalakis, {Zafiris J.} and Yuan, {Ti Fei}",
note = "Funding Information: We thank Chengyuan Cai, Ying Liu, Xiaoxiao Luo, Jianfei Yao, and Zhijun Yu for helps during data collection and management. The study was supported by NSFC grants (81822017, 31771215), The Science and Technology Commission of Shanghai Municipality (18QA1403700), Shanghai Municipal Education Commission - Gaofeng Clinical Medicine Grant Support (20181715), Hundred-talent Fund from Shanghai Municipal Commission of Health (2018BR21) to TFY. The work of ZJD is supported by the Canadian Institutes of Health Research (CIHR), the National Institutes of Mental Health (NIMH), Brain Canada and the Temerty Family and Grant Family and through the center for Addiction and Mental Health (CAMH) Foundation and the Campbell Institute. The funders have no role in study design, data collection, data analysis, interpretation, and writing of the report. TY and WL designed the study; XL, XZ, TL and QL performed the study; XL, XZ, LT, HZ, WL, ZJD and TY analyzed the results and wrote the paper together; all authors have read and approved the final version of the manuscript. ZJD has received research and equipment in-kind support for an investigator-initiated study through Brainsway Inc and Magventure Inc. None declared for rest authors. The original data is available from corresponding author upon request. Funding: National Natural Science Foundation of China; The Science and Technology Commission of Shanghai Municipality; Shanghai Municipal Education Commission; Shanghai Municipal Commission of Health; Canadian Institutes of Health Research (CIHR); the National Institutes of Mental Health (NIMH); Brain Canada and the Temerty Family and Grant Family and through the center for Addiction and Mental Health (CAMH) Foundation and the Campbell Institute. Funding Information: The study was supported by NSFC grants (81822017, 31771215), The Science and Technology Commission of Shanghai Municipality (18QA1403700), Shanghai Municipal Education Commission - Gaofeng Clinical Medicine Grant Support (20181715), Hundred-talent Fund from Shanghai Municipal Commission of Health (2018BR21) to TFY. The work of ZJD is supported by the Canadian Institutes of Health Research (CIHR), the National Institutes of Mental Health (NIMH), Brain Canada and the Temerty Family and Grant Family and through the center for Addiction and Mental Health (CAMH) Foundation and the Campbell Institute. Funding Information: Funding: National Natural Science Foundation of China; The Science and Technology Commission of Shanghai Municipality; Shanghai Municipal Education Commission; Shanghai Municipal Commission of Health; Canadian Institutes of Health Research (CIHR); the National Institutes of Mental Health (NIMH); Brain Canada and the Temerty Family and Grant Family and through the center for Addiction and Mental Health (CAMH) Foundation and the Campbell Institute. Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = jun,
doi = "10.1016/j.ebiom.2020.102809",
language = "English (US)",
volume = "56",
journal = "EBioMedicine",
issn = "2352-3964",
publisher = "Elsevier BV",
}