The effects of starvation and temperature acclimation on pentose phosphate pathway dehydrogenases in brook trout liver

Toshio Yamauchi*, John J. Stegeman, Erwin Goldberg

*Corresponding author for this work

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Temperature and starvation were found to be factors which affected the PPP dehydrogenase activities in brook trout liver. Fish acclimated at 5 °C possessed greater levels of G6PD, H6PD, and 6PGD activity than those fish maintained at 10 or 15 °C. This phenomenon was probably associated with increased lipogenesis during cold acclimation. During starvation hepatic G6PD and 6PGD activities decreased, whereas H6PD activity increased slightly. Upon refeeding, the G6PD level gradually increased, but the "overshoot" in enzyme activity reported in mammalian studies was not observed. When both cold acclimation and starvation were studied simultaneously, regulation by temperature was initially the dominant control factor. After 6 wk at 5 °C, there was no difference in specific activities between starved and fed fish. However, fish maintained at 5 °C for longer than 2 mo did show the normal response to starvation and refeeding. Therefore, regulation of the PPP by temperature appears to be a transitory phenomenon and may be associated with temporary metabolic reorganization in the fish.

Original languageEnglish (US)
Pages (from-to)13-20
Number of pages8
JournalArchives of biochemistry and biophysics
Volume167
Issue number1
DOIs
StatePublished - Mar 1975

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

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