The effects of subinhibitory concentrations of various antibiotics on phagocytosis of Streptococcus faecalis

E. M. Kennedy, N. Snowden, G. Westenfelder, J. P. Phair

Research output: Contribution to journalArticlepeer-review

Abstract

This study reports the effects of subinhibitory concentrations of the antibiotics, clindamycin, gentamicin, moxalactam, and penicillin G, against 6 blood isolates of Streptococcus faecalis to determine possible enhancement of phagocytosis. In addition, combinations of penicillin G plus streptomycin, penicillin G and gentamicin, and clindamycin plus gentamicin were studied to determine synergistic growth inhibition. Results suggest no observable effect in phagocytosis from subinhibitory concentrations of the studied antibiotics singly or in combination. The number of viable intracellular Str. faecalis were also not affected by pre-treatment with antibiotics.

Original languageEnglish (US)
Pages (from-to)69-74
Number of pages6
JournalJournal of Antimicrobial Chemotherapy
Volume12
Issue numberSUPPL. C
StatePublished - Dec 1 1983

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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