The effects of TMB-8 on acetylcholine release from frog motor nerve: interactions with adenosine

James M. Hunt; Eugene M Silinsky; Jody K. Hirsh; Dean Ahn; Carlos Solsona

doi:10.1016/0014-2999(90)90104-E

The effects of TMB-8 on acetylcholine release from frog motor nerve: interactions with adenosine

James M. Hunt, Eugene M Silinsky^*, Jody K. Hirsh, Dean Ahn, Carlos Solsona

^*Corresponding author for this work

Pharmacology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The putative intracellular calcium (Ca) antagonist TMB-8 was shown to reduce postjunctional sensitivity and quantal acetylcholine (ACh) release at low micromolar concentrations. At 10-fold higher concentrations, TMB-8 also blocked caffeine-induced Ca release (as monitored electrophysiologically by changes in ACh release) but did not impair the ability of adenosine to inhibit quantal ACh release. This last result implies that TMB-8 and adenosine exert their inhibitory actions at different steps in the depolarization-secretion coupling sequence.

Original language	English (US)
Pages (from-to)	259-266
Number of pages	8
Journal	European Journal of Pharmacology
Volume	178
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(90)90104-E
State	Published - Mar 27 1990

Keywords

Adenosine
TMB-8 Neurotransmitter release
neuromuscular junction

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(90)90104-E

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abstract = "The putative intracellular calcium (Ca) antagonist TMB-8 was shown to reduce postjunctional sensitivity and quantal acetylcholine (ACh) release at low micromolar concentrations. At 10-fold higher concentrations, TMB-8 also blocked caffeine-induced Ca release (as monitored electrophysiologically by changes in ACh release) but did not impair the ability of adenosine to inhibit quantal ACh release. This last result implies that TMB-8 and adenosine exert their inhibitory actions at different steps in the depolarization-secretion coupling sequence.",

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AU - Ahn, Dean

AU - Solsona, Carlos

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Y1 - 1990/3/27

N2 - The putative intracellular calcium (Ca) antagonist TMB-8 was shown to reduce postjunctional sensitivity and quantal acetylcholine (ACh) release at low micromolar concentrations. At 10-fold higher concentrations, TMB-8 also blocked caffeine-induced Ca release (as monitored electrophysiologically by changes in ACh release) but did not impair the ability of adenosine to inhibit quantal ACh release. This last result implies that TMB-8 and adenosine exert their inhibitory actions at different steps in the depolarization-secretion coupling sequence.

AB - The putative intracellular calcium (Ca) antagonist TMB-8 was shown to reduce postjunctional sensitivity and quantal acetylcholine (ACh) release at low micromolar concentrations. At 10-fold higher concentrations, TMB-8 also blocked caffeine-induced Ca release (as monitored electrophysiologically by changes in ACh release) but did not impair the ability of adenosine to inhibit quantal ACh release. This last result implies that TMB-8 and adenosine exert their inhibitory actions at different steps in the depolarization-secretion coupling sequence.

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The effects of TMB-8 on acetylcholine release from frog motor nerve: interactions with adenosine

Abstract

Keywords

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