Abstract
The putative intracellular calcium (Ca) antagonist TMB-8 was shown to reduce postjunctional sensitivity and quantal acetylcholine (ACh) release at low micromolar concentrations. At 10-fold higher concentrations, TMB-8 also blocked caffeine-induced Ca release (as monitored electrophysiologically by changes in ACh release) but did not impair the ability of adenosine to inhibit quantal ACh release. This last result implies that TMB-8 and adenosine exert their inhibitory actions at different steps in the depolarization-secretion coupling sequence.
Original language | English (US) |
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Pages (from-to) | 259-266 |
Number of pages | 8 |
Journal | European Journal of Pharmacology |
Volume | 178 |
Issue number | 3 |
DOIs | |
State | Published - Mar 27 1990 |
Keywords
- Adenosine
- TMB-8 Neurotransmitter release
- neuromuscular junction
ASJC Scopus subject areas
- Pharmacology