The effects of TMB-8 on acetylcholine release from frog motor nerve: interactions with adenosine

James M. Hunt, Eugene M Silinsky*, Jody K. Hirsh, Dean Ahn, Carlos Solsona

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The putative intracellular calcium (Ca) antagonist TMB-8 was shown to reduce postjunctional sensitivity and quantal acetylcholine (ACh) release at low micromolar concentrations. At 10-fold higher concentrations, TMB-8 also blocked caffeine-induced Ca release (as monitored electrophysiologically by changes in ACh release) but did not impair the ability of adenosine to inhibit quantal ACh release. This last result implies that TMB-8 and adenosine exert their inhibitory actions at different steps in the depolarization-secretion coupling sequence.

Original languageEnglish (US)
Pages (from-to)259-266
Number of pages8
JournalEuropean Journal of Pharmacology
Volume178
Issue number3
DOIs
StatePublished - Mar 27 1990

Keywords

  • Adenosine
  • TMB-8 Neurotransmitter release
  • neuromuscular junction

ASJC Scopus subject areas

  • Pharmacology

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