The emergence, localization, and maturation of neurotransmitter systems during development of the retina in xenopus laevis: II. Glycine

Mary E. Rayborn, P. Vijay Sarthy, Dominic M K Lam, Joe G. Hollyfield*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

The high‐affinity uptake and release of glycine was studied in retinas of Xenopus laevis. In the toad and tadpole retina, 3H‐glycine was accumulated by a population of cells located predominantly in the inner nuclear layer. When retinas preloaded with 3H‐glycine were subjected to high K+‐concentrations, these retinas released large amounts of 3H‐glycine by a Ca++‐dependent mechanism. The appearance and maturation of these putative glycinergic properties was followed during retinal development. Our results indicate that the high‐affinity uptake of glycine first appears around stage 33/34 whereas K+‐stimulated glycine release cannot be detected until stage 42.

Original languageEnglish (US)
Pages (from-to)585-593
Number of pages9
JournalJournal of Comparative Neurology
Volume195
Issue number4
DOIs
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Neuroscience(all)

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