TY - JOUR
T1 - The Emerging Complexity of the Vertebrate Cilium
T2 - New Functional Roles for an Ancient Organelle
AU - Davis, Erica Ellen
AU - Brueckner, Martina
AU - Katsanis, Elias Nicholas
N1 - Funding Information:
We apologize to our colleagues whose insightful work was not included due to size constraints. We are indebted to Jantje Gerdes and Norann Zaghloul for their thoughtful critiques of our manuscript. This work was supported by grants R01HD045789 (M.B.) and R01HD04260 (N.K.) from the National Institute of Child Health and Development and R01DK072301 (N.K.) from the National Institute of Diabetes, Digestive, and Kidney Disorders.
PY - 2006/7
Y1 - 2006/7
N2 - Cilia and flagella are found on the surface of a strikingly diverse range of cell types. These intriguing organelles, with their unique and highly adapted protein transport machinery, have been studied extensively in the context of cellular locomotion, sexual reproduction, or fluid propulsion. However, recent studies are beginning to show that in vertebrates particularly, cilia have been recruited to perform additional developmental and homeostatic roles. Here, we review advances in deciphering the functional components of cilia, and we explore emerging trends that implicate ciliary proteins in signal transduction and morphogenetic pathways.
AB - Cilia and flagella are found on the surface of a strikingly diverse range of cell types. These intriguing organelles, with their unique and highly adapted protein transport machinery, have been studied extensively in the context of cellular locomotion, sexual reproduction, or fluid propulsion. However, recent studies are beginning to show that in vertebrates particularly, cilia have been recruited to perform additional developmental and homeostatic roles. Here, we review advances in deciphering the functional components of cilia, and we explore emerging trends that implicate ciliary proteins in signal transduction and morphogenetic pathways.
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U2 - 10.1016/j.devcel.2006.06.009
DO - 10.1016/j.devcel.2006.06.009
M3 - Review article
C2 - 16824949
AN - SCOPUS:33745496759
SN - 1534-5807
VL - 11
SP - 9
EP - 19
JO - Developmental Cell
JF - Developmental Cell
IS - 1
ER -