The emerging genetic landscape underlying cardiac conduction system function

David E. Arnolds, Alison Chu, Elizabeth M. Mcnally, Marcelo A. Nobrega, Ivan P. Moskowitz*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Proper function of an organized Cardiac Conduction System (CCS) is vital to the survival of metazoans ranging from fly to man. The routine use of non-invasive electrocardiogram measures in the diagnosis and monitoring of cardiovascular health has established a trove of reliable CCS functional data in both normal and diseased cardiac states. Recent combination of echocardiogram (ECG) data with genome-wide association studies has identified genomic regions implicated in ECG variability which impact CCS function. In this study, we review the substantial recent progress in this area, highlighting the identification of novel loci, confirming the importance of previously implicated loci in CCS function, and exploring potential links between genes with important roles in developmental processes and variation in function of the CCS.

Original languageEnglish (US)
Pages (from-to)578-585
Number of pages8
JournalBirth Defects Research Part A - Clinical and Molecular Teratology
Issue number6
StatePublished - Jun 2011


  • Cardiac
  • Conduction
  • Development
  • GWAS
  • Heart
  • T-box
  • Transcription factor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Developmental Biology


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