The emerging role of APC/CCdh1 in development

Dong Hu; Xinxian Qiao; George Wu; Yong Wan

doi:10.1016/j.semcdb.2011.03.012

The emerging role of APC/C^Cdh1 in development

Dong Hu, Xinxian Qiao, George Wu, Yong Wan^*

^*Corresponding author for this work

Obstetrics and Gynecology

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

The function of APC/C (anaphase-promoting complex/cyclosome) was initially implicated with the onset of anaphase during mitosis, where its association with Cdc20 targets securin for destruction, thereby allowing the separation of two duplicated daughter genomes. When combined with Cdh1, APC regulates G1/S transition and DNA replication during cell cycle. Beyond cell cycle control, results from recent biochemical and mouse genetic studies have attracted our attention to the unexpected impact of APC/C^Cdh1 in cellular differentiation, genomic integrity and pathogenesis of various diseases. This review will aim to summarize current understanding of APC/C^Cdh1 in regulating crucial events during development.

Original language	English (US)
Pages (from-to)	579-585
Number of pages	7
Journal	Seminars in Cell and Developmental Biology
Volume	22
Issue number	6
DOIs	https://doi.org/10.1016/j.semcdb.2011.03.012
State	Published - Aug 2011

Keywords

APC/C
Cdh1
Cell cycle
Development
Differentiation
Ubiquitylation

ASJC Scopus subject areas

Cell Biology
Developmental Biology

Access to Document

10.1016/j.semcdb.2011.03.012

Cite this

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title = "The emerging role of APC/CCdh1 in development",

abstract = "The function of APC/C (anaphase-promoting complex/cyclosome) was initially implicated with the onset of anaphase during mitosis, where its association with Cdc20 targets securin for destruction, thereby allowing the separation of two duplicated daughter genomes. When combined with Cdh1, APC regulates G1/S transition and DNA replication during cell cycle. Beyond cell cycle control, results from recent biochemical and mouse genetic studies have attracted our attention to the unexpected impact of APC/CCdh1 in cellular differentiation, genomic integrity and pathogenesis of various diseases. This review will aim to summarize current understanding of APC/CCdh1 in regulating crucial events during development.",

keywords = "APC/C, Cdh1, Cell cycle, Development, Differentiation, Ubiquitylation",

author = "Dong Hu and Xinxian Qiao and George Wu and Yong Wan",

note = "Funding Information: The laboratory work is kindly supported by NIH grant CA115943 . Y. Wan is a scholar of the American Cancer Society.",

year = "2011",

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T1 - The emerging role of APC/CCdh1 in development

AU - Hu, Dong

AU - Qiao, Xinxian

AU - Wu, George

AU - Wan, Yong

N1 - Funding Information: The laboratory work is kindly supported by NIH grant CA115943 . Y. Wan is a scholar of the American Cancer Society.

PY - 2011/8

Y1 - 2011/8

N2 - The function of APC/C (anaphase-promoting complex/cyclosome) was initially implicated with the onset of anaphase during mitosis, where its association with Cdc20 targets securin for destruction, thereby allowing the separation of two duplicated daughter genomes. When combined with Cdh1, APC regulates G1/S transition and DNA replication during cell cycle. Beyond cell cycle control, results from recent biochemical and mouse genetic studies have attracted our attention to the unexpected impact of APC/CCdh1 in cellular differentiation, genomic integrity and pathogenesis of various diseases. This review will aim to summarize current understanding of APC/CCdh1 in regulating crucial events during development.

AB - The function of APC/C (anaphase-promoting complex/cyclosome) was initially implicated with the onset of anaphase during mitosis, where its association with Cdc20 targets securin for destruction, thereby allowing the separation of two duplicated daughter genomes. When combined with Cdh1, APC regulates G1/S transition and DNA replication during cell cycle. Beyond cell cycle control, results from recent biochemical and mouse genetic studies have attracted our attention to the unexpected impact of APC/CCdh1 in cellular differentiation, genomic integrity and pathogenesis of various diseases. This review will aim to summarize current understanding of APC/CCdh1 in regulating crucial events during development.

KW - APC/C

KW - Cdh1

KW - Cell cycle

KW - Development

KW - Differentiation

KW - Ubiquitylation

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