The emerging role of APC/CCdh1 in development

Dong Hu, Xinxian Qiao, George Wu, Yong Wan*

*Corresponding author for this work

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

The function of APC/C (anaphase-promoting complex/cyclosome) was initially implicated with the onset of anaphase during mitosis, where its association with Cdc20 targets securin for destruction, thereby allowing the separation of two duplicated daughter genomes. When combined with Cdh1, APC regulates G1/S transition and DNA replication during cell cycle. Beyond cell cycle control, results from recent biochemical and mouse genetic studies have attracted our attention to the unexpected impact of APC/CCdh1 in cellular differentiation, genomic integrity and pathogenesis of various diseases. This review will aim to summarize current understanding of APC/CCdh1 in regulating crucial events during development.

Original languageEnglish (US)
Pages (from-to)579-585
Number of pages7
JournalSeminars in Cell and Developmental Biology
Volume22
Issue number6
DOIs
StatePublished - Jan 1 2011

Keywords

  • APC/C
  • Cdh1
  • Cell cycle
  • Development
  • Differentiation
  • Ubiquitylation

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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