The emerging role of microRNAs in drug responses

Wei Zhang, M. Eileen Dolan

Research output: Contribution to journalReview article

36 Scopus citations

Abstract

In recent years, pharmacogenomic research has begun to integrate genetics, gene expression and pharmacological phenotypes. MicroRNAs (miRNAs), 21-to 25-nucleotide, non-coding RNAs that are present in almost all metazoan genomes, are a class of gene regulators that downregulate gene expression at the post-transcriptional level. Experimental evidence for the role of miRNAs in regulating pharmacology-related genes and drug responses is increasing. Given the universal roles of miRNAs in various diseases, including cancer, miRNAs (eg, chemotherapy) are anticipated to have potential therapeutic effects in various diseases. The incorporation of miRNAs into pharmacogenomic research could provide improved insight into drug responses. However, more studies are necessary to evaluate the effects of these molecules in patients.

Original languageEnglish (US)
Pages (from-to)695-702
Number of pages8
JournalCurrent Opinion in Molecular Therapeutics
Volume12
Issue number6
StatePublished - Dec 1 2010

Keywords

  • Drug response
  • gene expression
  • gene regulation
  • microRNA
  • miRNA
  • pharmacogene
  • pharmacogenomic

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery
  • Genetics(clinical)

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