The emerging role of MMP14 in brain tumorigenesis and future therapeutics

Ilya Ulasov, Ruiyang Yi, Donna Guo, Purvaba Sarvaiya, Charles Cobbs*

*Corresponding author for this work

Research output: Contribution to journalReview article

35 Scopus citations

Abstract

Glioblastoma is a malignant brain tumor of glial origin. These tumors are thought to be derived from astrocytic cells that undergo malignant transformation. A growing body of evidence suggests that upregulation of MMP expression plays a significant role in promoting glioma pathogenesis. Elevated expression of MMP14 not only promotes glioma invasion and tumor cell proliferation but also plays a role in angiogenesis. Despite the fact that levels of MMP14 correlate with breast cancer progression, the controversial role of MMP14 in gliomagenesis needs to be elucidated. In the present review, we discuss the role of MMP14 in glioma progression as well as the mechanisms of MMP14 regulation in the context of future therapeutic manipulations.

Original languageEnglish (US)
Pages (from-to)113-120
Number of pages8
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1846
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • Angiogenesis
  • Brain
  • Glioblastoma
  • Invasion
  • MMP14
  • Tumor

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

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