The emerging role of the ubiquitin proteasome in pulmonary biology and disease

Nathaniel M. Weathington; Jacob I. Sznajder; Rama K. Mallampalli

doi:10.1164/rccm.201304-0754PP

The emerging role of the ubiquitin proteasome in pulmonary biology and disease

Nathaniel M. Weathington, Jacob I. Sznajder, Rama K. Mallampalli

Medicine, Pulmonary Division

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

Derangements in normal cellular homeostasis at the protein level can cause or be the consequence of initiation and progression of pulmonary diseases related to genotype, infection, injury, smoking, toxin exposure, or neoplasm. We discuss one of the fundamental mechanisms of protein homeostasis, the ubiquitin proteasome system (UPS), as it relates to lung disease. The UPS effects selective degradation of ubiquitinated target proteins via ubiquitin ligase activity. Important pathobiological mechanisms relating to the UPS and lung disease have been the focus of research, with inappropriate cellular proteolysis now a validated therapeutic target. We review the contributions of this system in various lung diseases, and discuss the exciting area of UPS-targeting drug development for pulmonary disease.

Original language	English (US)
Pages (from-to)	530-537
Number of pages	8
Journal	American journal of respiratory and critical care medicine
Volume	188
Issue number	5
DOIs	https://doi.org/10.1164/rccm.201304-0754PP
State	Published - Sep 1 2013

Funding

Keywords

Drug development
E3 ligase
Proteasome
Pulmonary disease
Ubiquitin

ASJC Scopus subject areas

Critical Care and Intensive Care Medicine
Pulmonary and Respiratory Medicine

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10.1164/rccm.201304-0754PP

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The emerging role of the ubiquitin proteasome in pulmonary biology and disease

Abstract

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Keywords

ASJC Scopus subject areas

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