The emerging role of the ubiquitin proteasome in pulmonary biology and disease

Nathaniel M. Weathington, Jacob I. Sznajder, Rama K. Mallampalli

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

Derangements in normal cellular homeostasis at the protein level can cause or be the consequence of initiation and progression of pulmonary diseases related to genotype, infection, injury, smoking, toxin exposure, or neoplasm. We discuss one of the fundamental mechanisms of protein homeostasis, the ubiquitin proteasome system (UPS), as it relates to lung disease. The UPS effects selective degradation of ubiquitinated target proteins via ubiquitin ligase activity. Important pathobiological mechanisms relating to the UPS and lung disease have been the focus of research, with inappropriate cellular proteolysis now a validated therapeutic target. We review the contributions of this system in various lung diseases, and discuss the exciting area of UPS-targeting drug development for pulmonary disease.

Original languageEnglish (US)
Pages (from-to)530-537
Number of pages8
JournalAmerican journal of respiratory and critical care medicine
Volume188
Issue number5
DOIs
StatePublished - Sep 1 2013

Keywords

  • Drug development
  • E3 ligase
  • Proteasome
  • Pulmonary disease
  • Ubiquitin

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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