The enantioselective synthesis of conformationally constrained cyclic β-amino acids

Jason A. Miller, Son Binh T. Nguyen*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations

Abstract

Enantiomerically pure and conformationally constrained cyclic β-amino acids have been the subject of a vast amount of research across the chemical, biological, and medicinal disciplines. These valuable molecules are synthetic precursors for a wide variety of useful compounds that include natural products and modified peptides. Many methods have been developed to prepare chiral cyclic β-amino acids in high optical purity. This mini-review will discuss some of the most recent and successful approaches.

Original languageEnglish (US)
Pages (from-to)39-45
Number of pages7
JournalMini-Reviews in Organic Chemistry
Volume2
Issue number1
DOIs
StatePublished - Jan 1 2005

Keywords

  • Asymmetric synthesis
  • Conformationally constrained
  • Cyclic β-amino acids
  • Enantioselective synthesis
  • Peptides
  • β-amino acids

ASJC Scopus subject areas

  • Organic Chemistry

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