The endogenous circadian clock programs animals to eat at certain times of the 24-hour day: What if we ignore the clock?

Peng Jiang, Fred W. Turek*

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The discovery of the molecular mechanisms underlying the circadian clock, which functions in virtually every cell throughout the body to coordinate biological processes to anticipate and better adapt to daily rhythmic changes in the environment, is one of the major biomedical breakthroughs in the 20th century. Twenty years after this breakthrough, the biomedical community is now at a new frontier to incorporate the circadian clock mechanisms into many areas of biomedical research, as studies continue to reveal an important role of the circadian clock in a wide range of biological functions and diseases. A forefront of this exciting area is the research of interactions between the clock and energy metabolism. In this review, we summarize animal and human studies linking disruptions of the circadian clock, either environmental or genetic, to metabolic dysfunctions associated with obesity, diabetes, and other metabolic disorders. We also discuss how these advances in circadian biology may pave the way to revolutionize clinical practice in the era of precision medicine.

Original languageEnglish (US)
Pages (from-to)211-217
Number of pages7
JournalPhysiology and Behavior
Volume193
DOIs
StatePublished - Sep 1 2018

Keywords

  • Circadian clock
  • Diabetes
  • Energy metabolism
  • Obesity

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

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