The enigmatic role of Sir2 in aging

Brian K. Kennedy; Erica D. Smith; Matt Kaeberlein

doi:10.1016/j.cell.2005.11.002

The enigmatic role of Sir2 in aging

Brian K. Kennedy^*, Erica D. Smith, Matt Kaeberlein

^*Corresponding author for this work

Cell & Developmental Biology

Research output: Contribution to journal › Short survey › peer-review

47 Scopus citations

Abstract

In this issue of Cell, Longo and colleagues (Fabrizio et al., 2005) examine the role of Sir2, a histone deacetylase, in chronological aging in yeast by measuring the long-term survival of nondividing cells. In contrast to measurements of aging for mitotic cells, cell survival in the nonmitotic state is decreased by Sir2 activity under conditions that mimic calorie restriction.

Original language	English (US)
Pages (from-to)	548-550
Number of pages	3
Journal	Cell
Volume	123
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2005.11.002
State	Published - Nov 18 2005

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2005.11.002

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title = "The enigmatic role of Sir2 in aging",

abstract = "In this issue of Cell, Longo and colleagues (Fabrizio et al., 2005) examine the role of Sir2, a histone deacetylase, in chronological aging in yeast by measuring the long-term survival of nondividing cells. In contrast to measurements of aging for mitotic cells, cell survival in the nonmitotic state is decreased by Sir2 activity under conditions that mimic calorie restriction.",

author = "Kennedy, {Brian K.} and Smith, {Erica D.} and Matt Kaeberlein",

year = "2005",

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journal = "Cell",

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T1 - The enigmatic role of Sir2 in aging

AU - Kennedy, Brian K.

AU - Smith, Erica D.

AU - Kaeberlein, Matt

PY - 2005/11/18

Y1 - 2005/11/18

N2 - In this issue of Cell, Longo and colleagues (Fabrizio et al., 2005) examine the role of Sir2, a histone deacetylase, in chronological aging in yeast by measuring the long-term survival of nondividing cells. In contrast to measurements of aging for mitotic cells, cell survival in the nonmitotic state is decreased by Sir2 activity under conditions that mimic calorie restriction.

AB - In this issue of Cell, Longo and colleagues (Fabrizio et al., 2005) examine the role of Sir2, a histone deacetylase, in chronological aging in yeast by measuring the long-term survival of nondividing cells. In contrast to measurements of aging for mitotic cells, cell survival in the nonmitotic state is decreased by Sir2 activity under conditions that mimic calorie restriction.

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U2 - 10.1016/j.cell.2005.11.002

DO - 10.1016/j.cell.2005.11.002

M3 - Short survey

C2 - 16286003

AN - SCOPUS:27744554550

SN - 0092-8674

VL - 123

SP - 548

EP - 550

JO - Cell

JF - Cell

IS - 4

ER -

The enigmatic role of Sir2 in aging

Abstract

ASJC Scopus subject areas

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