The enigmatic role of Sir2 in aging

Brian K. Kennedy*, Erica D. Smith, Matt Kaeberlein

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

46 Scopus citations


In this issue of Cell, Longo and colleagues (Fabrizio et al., 2005) examine the role of Sir2, a histone deacetylase, in chronological aging in yeast by measuring the long-term survival of nondividing cells. In contrast to measurements of aging for mitotic cells, cell survival in the nonmitotic state is decreased by Sir2 activity under conditions that mimic calorie restriction.

Original languageEnglish (US)
Pages (from-to)548-550
Number of pages3
Issue number4
StatePublished - Nov 18 2005

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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