The enkephalins - Peptides with morphine-like activity

Richard J. Miller*, Pedro Cuatrecasas

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Two penta-peptides with morphine-like properties have recently been found in the nervous system and gastrointestinal tract. These peptides known as enkephalins are unevenly distributed in the brain, the highest concentration being in the globus pallidus. The enkephalins are found to have analgesic properties and are also anti-tussive, anti-diarrheal and able to stimulate release of prolactin and growth hormone. Synthetic analogues of the enkephalins containing specific D-amino acid substitutions have been developed and show a wide spectrum of activities.

Original languageEnglish (US)
Pages (from-to)507-514
Number of pages8
Issue number10
StatePublished - Oct 1 1978

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics


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