The epidemiology and clinical implications of genetic variation in prostate cancer

Brian T. Helfand*, William J Catalona

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

There is strong evidence of a genetic predisposition to prostate cancer. Recent advances in genetic sequencing technologies have permitted significant advances in the field. This article reviews the genetic basis underlying prostate cancer, and highlights the epidemiology and potential clinical usefulness of both rare and common genetic variations. In addition, recent findings related to the understanding of prostate cancer genetics are discussed.

Original languageEnglish (US)
Pages (from-to)277-297
Number of pages21
JournalUrologic Clinics of North America
Volume41
Issue number2
DOIs
StatePublished - Jan 1 2014

Keywords

  • Genetic variants
  • Prostate cancer
  • Susceptibility
  • Tumor aggressiveness

ASJC Scopus subject areas

  • Urology

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