The epigenome as a molecular marker and target: Implications for cancer

David Gius*, C. Matthew Bradbury, Lunching Sun, Rania T. Awwad, Lei Huang, Dee Dee K Smart, Kheem S. Bisht, Alien S. Ho, Phuongmai Nguyen

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Tumor cell proliferation, de-differentiation, and progression depend on a complex combination of altered cell cycle regulation, excessive growth factor pathway activation, and decreased apoptosis. The understanding of these complex mechanisms should lead to the identification of potential molecular markers, targets, and molecular profiles that should eventually expand and improve therapeutic intervention. It now appears clear that methylation plays a central role in transformation, both in vitro and in vivo. However, the exact targets and mechanism(s) are not yet fully understood. This is partly due to the significant number of genes altered by changes in intracellular methyltransferase activity and the chemical agents used to modulate gene expression. The complex nature of methylation's role in regulating gene expression suggests that in addition to investigating individual genes, researchers should develop more comprehensive methods to examine gene expression patterns and their predictive value as this will likely be necessary in the future. If methylation plays a role in transformation, then it seems logical that genes regulating intracellular methylation status may be used as molecular markers to profile tumors by any new methods currently being developed. Perhaps more noteworthy is that DNMT genes may be found to be novel molecular targets for new factor-specific anticancer agents. This idea will be addressed.

Original languageEnglish (US)
Pages (from-to)1789-1793
Number of pages5
JournalCancer
Volume104
Issue number9
DOIs
StatePublished - Oct 26 2005

Keywords

  • DNMT
  • Epigenome
  • Methylation
  • Molecular marker

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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