The estrogen receptor: Mechanism of action and relationship to human breast cancer

F. E. Murdoch, M. Fritsch, J. Gorski

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Approximately one-third of human breast cancer patients derive a significant clinical benefit from some type of endocrine therapy. These therapeutic procedures are generally designed to either decrease estrogen production in the patient or interfere with its action. A large body of experimental evidence supports the hypothesis that the growth of breast tumors is directly dependent upon estrogen. Identification of the subset of human breast cancer patients that are likely to respond to endocrine therapy is a prime clinical priority. Basic research on the mechanism of estrogen action has led to the identification and characterization of the estrogen receptor protein. Large-scale screenings of breast tumors for the presence of the estrogen receptor have demonstrated a positive correlation between the presence of the protein and the probability of responding to therapy. Current studies are directed at understanding the mechanism of receptor-mediated tumor growth and the progression of breast cancer tumors to a hormone-independent state.

Original languageEnglish (US)
Pages (from-to)267-275
Number of pages9
JournalISI Atlas of Science: Pharmacology
Issue number3
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

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