The etiology of neural tube defects: The role of folic acid

David G. McLone

doi:10.1007/s00381-003-0793-2

The etiology of neural tube defects: The role of folic acid

David G. McLone^*

^*Corresponding author for this work

Neurological Surgery

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Discussion: While the cause of neural tube defects in humans is considered to be multifactorial, it is apparent that folic acid can prevent 70% of open neural tube defects. Even in laboratory animals with known genetic defects, folic acid can prevent the genetic expression. Conclusion: While some of the metabolic pathways for folic acid are known, the true effects of folic acid on closure of the neural tube have yet to be discovered.

Original language	English (US)
Pages (from-to)	537-539
Number of pages	3
Journal	Child's Nervous System
Volume	19
Issue number	7-8
DOIs	https://doi.org/10.1007/s00381-003-0793-2
State	Published - Aug 1 2003

Keywords

Folic acid
Neural tube defects
Spina bifida

ASJC Scopus subject areas

Clinical Neurology
Pediatrics, Perinatology, and Child Health

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10.1007/s00381-003-0793-2

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AB - Discussion: While the cause of neural tube defects in humans is considered to be multifactorial, it is apparent that folic acid can prevent 70% of open neural tube defects. Even in laboratory animals with known genetic defects, folic acid can prevent the genetic expression. Conclusion: While some of the metabolic pathways for folic acid are known, the true effects of folic acid on closure of the neural tube have yet to be discovered.

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KW - Spina bifida

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The etiology of neural tube defects: The role of folic acid

Abstract

Keywords

ASJC Scopus subject areas

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