The etiology of neural tube defects: The role of folic acid

David G McLone*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Discussion: While the cause of neural tube defects in humans is considered to be multifactorial, it is apparent that folic acid can prevent 70% of open neural tube defects. Even in laboratory animals with known genetic defects, folic acid can prevent the genetic expression. Conclusion: While some of the metabolic pathways for folic acid are known, the true effects of folic acid on closure of the neural tube have yet to be discovered.

Original languageEnglish (US)
Pages (from-to)537-539
Number of pages3
JournalChild's Nervous System
Issue number7-8
StatePublished - Aug 1 2003


  • Folic acid
  • Neural tube defects
  • Spina bifida

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


Dive into the research topics of 'The etiology of neural tube defects: The role of folic acid'. Together they form a unique fingerprint.

Cite this