The etiology of polycystic ovary syndrome (PCO)

R. Kazer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Consideration of existing data leads to the hypothesis that polycystic ovary syndrome results from a primary abnormality in the growth hormone (GH)-insulin-like growth factor 1 (IGF-1) axis characterized by increased IGF-1 activity at multiple sites. The effect of elevated IGF-1 activity upon the ovary, the adrenal, and on peripheral tissues may lead to the clinical and biochemical features of PCO, including hyperandrogenemic chronic anovulation, insulin resistance, and elevated adrenal androgen secretion. The fundamental defect may be a consequence of feeding behavior early in life.

Original languageEnglish (US)
Pages (from-to)151-155
Number of pages5
JournalMedical Hypotheses
Issue number3
StatePublished - Nov 1989

ASJC Scopus subject areas

  • Medicine(all)

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