The Ets-1 transcription factor is required for the development of natural killer cells in mice

Kevin Barton, Natarajan Muthusamy, Christopher Fischer, Chao Nan Ting, Theresa L. Walunas, Lewis L. Lanier, Jeffrey M. Leiden*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

287 Scopus citations

Abstract

In this report we have investigated the role of the Ets-1 transcription factor in the differentiation of the NK cell lineage in mice. Splenic NK cells express high levels of Ets-1. Ets-1-deficient mice produced by gene targeting developed mature erythrocytes, monocytes, neutrophils, and T and B lymphocytes. However, spleens from the Ets-1-deficient mice contained significantly reduced numbers of natural killer (NK) cells, and splenocytes from these mice lacked detectable cytolytic activity against NK cell targets in vitro. Moreover, unlike wild-type animals, Ets-1-deficient mice developed tumors following subcutaneous injection of NK-susceptible RMA-S cells. These NK cell defects could not be correlated with defects in the expression of IL- 12, IL-15, and IL-18 or the IL-2 or IL-15 receptors. Thus, Ets-1 defines a novel transcriptional pathway that is required for the development of the NK cell lineage in mice.

Original languageEnglish (US)
Pages (from-to)555-563
Number of pages9
JournalImmunity
Volume9
Issue number4
DOIs
StatePublished - Oct 1998

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'The Ets-1 transcription factor is required for the development of natural killer cells in mice'. Together they form a unique fingerprint.

Cite this