The expression of fgfr3 in the zebrafish head

Joanna K. Ledwon, Sergey Y. Turin, Arun K. Gosain, Jolanta M. Topczewska*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Fibroblast growth factor (FGF) signaling is essential for many developmental processes and plays a pivotal role in skeletal homeostasis, regeneration and wound healing. FGF signals through one of five tyrosine kinase receptors: Fgfr1a, -1b, −2, −3, −4. To characterize the expression of zebrafish fgfr3 from the larval stage to adulthood, we used RNAscope in situ hybridization on paraffin sections of the zebrafish head. Our study revealed spatial and temporal distribution of fgfr3 transcript in chondrocytes of the head cartilages, osteoblasts involved in bone formation, ventricular zone of the brain, undifferentiated mesenchymal cells of the skin, and lens epithelium of the eye. In general, the expression pattern of zebrafish fgfr3 is similar to the expression observed in higher vertebrates.

Original languageEnglish (US)
Pages (from-to)32-38
Number of pages7
JournalGene Expression Patterns
Volume29
DOIs
StatePublished - Sep 2018

Keywords

  • Bone cranium
  • Cartilage
  • Chondroclasts
  • Chondrocyte
  • Osteoblast
  • Osteoclasts
  • Zebrafish
  • fgfr3

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Developmental Biology

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