The Ezrin-Radixin-Moesin family member Ezrin regulates stable microtubule formation and retroviral infection

Juliane Haedicke, Kenia De Los Santos, Stephen P. Goff, Mojgan H. Naghavi

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

We recently identified the cytoskeletal regulatory protein moesin as a novel gene that inhibits retroviral replication prior to reverse transcription by downregulation of stable microtubule formation. Here, we provide evidence that overexpression of ezrin, another closely related ezrin-radixin-moesin (ERM) family member, also blocks replication of both murine leukemia viruses and human immunodeficiency virus type 1 (HIV-1) in Rat2 fibroblasts before reverse transcription, while knockdown of endogenous ezrin increases the susceptibility of human cells to HIV-1 infection. Together, these results suggest that ERM proteins may be important determinants of retrovirus susceptibility through negative regulation of stable microtubule networks.

Original languageEnglish (US)
Pages (from-to)4665-4670
Number of pages6
JournalJournal of virology
Volume82
Issue number9
DOIs
StatePublished - May 1 2008

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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