Abstract
We recently identified the cytoskeletal regulatory protein moesin as a novel gene that inhibits retroviral replication prior to reverse transcription by downregulation of stable microtubule formation. Here, we provide evidence that overexpression of ezrin, another closely related ezrin-radixin-moesin (ERM) family member, also blocks replication of both murine leukemia viruses and human immunodeficiency virus type 1 (HIV-1) in Rat2 fibroblasts before reverse transcription, while knockdown of endogenous ezrin increases the susceptibility of human cells to HIV-1 infection. Together, these results suggest that ERM proteins may be important determinants of retrovirus susceptibility through negative regulation of stable microtubule networks.
Original language | English (US) |
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Pages (from-to) | 4665-4670 |
Number of pages | 6 |
Journal | Journal of virology |
Volume | 82 |
Issue number | 9 |
DOIs | |
State | Published - May 2008 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology