The facile conversion of T-2 toxin and neosolaniol into anguidine

Derek W. Anderson*, Robin M. Black, David A. Leigh, J. Fraser Stoddart, Nancy E. Williams

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

T-2 Toxin (5) and neosolaniol (6) are readily converted into anguidine (1) by a procedure where deoxygenation at the C-8 position is achieved, after conversion of the 3-TBDMS ether 7 of neosolaniol (6) to the β-bromide 11 for reduction to the anguidine precursor 12.

Original languageEnglish (US)
Pages (from-to)2661-2664
Number of pages4
JournalTetrahedron Letters
Volume28
Issue number23
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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