The filtration characteristics of the aqueous outflow system

Mark Johnson; Douglas H. Johnson; Roger D. Kamm; Annelies W. DeKater; David L. Epstein

doi:10.1016/0014-4835(90)90142-H

The filtration characteristics of the aqueous outflow system

Mark Johnson^*, Douglas H. Johnson, Roger D. Kamm, Annelies W. DeKater, David L. Epstein

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

To determine the filtration characteristics of the aqueous outflow system, microspheres (0·18 μm-1·1 μm) were perfused through enucleated human and bovine eyes. The microspheres were smaller than morphologically determined flow dimensions, and yet a significant fraction of all sizes of microspheres were captured. The bovine (calf) aqueous outflow system was found to be a far more efficient filter than was the human outflow system. Combining the experimental results with morphological observations and theoretical calculations leads to the conclusion that 'sticky wall' interactions are responsible for much of the microsphere capture, and that the site of filtration may be distinct from the site of flow resistance. Consequently, the dimension of the sites generating flow resistance cannot be determined from filtration studies.

Original language	English (US)
Pages (from-to)	407-418
Number of pages	12
Journal	Experimental eye research
Volume	50
Issue number	4
DOIs	https://doi.org/10.1016/0014-4835(90)90142-H
State	Published - Apr 1990

Keywords

bovine
filtration
human
microspheres
trabecular meshwork

ASJC Scopus subject areas

Sensory Systems
Cellular and Molecular Neuroscience
Ophthalmology

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10.1016/0014-4835(90)90142-H

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title = "The filtration characteristics of the aqueous outflow system",

abstract = "To determine the filtration characteristics of the aqueous outflow system, microspheres (0·18 μm-1·1 μm) were perfused through enucleated human and bovine eyes. The microspheres were smaller than morphologically determined flow dimensions, and yet a significant fraction of all sizes of microspheres were captured. The bovine (calf) aqueous outflow system was found to be a far more efficient filter than was the human outflow system. Combining the experimental results with morphological observations and theoretical calculations leads to the conclusion that 'sticky wall' interactions are responsible for much of the microsphere capture, and that the site of filtration may be distinct from the site of flow resistance. Consequently, the dimension of the sites generating flow resistance cannot be determined from filtration studies.",

keywords = "bovine, filtration, human, microspheres, trabecular meshwork",

author = "Mark Johnson and Johnson, {Douglas H.} and Kamm, {Roger D.} and DeKater, {Annelies W.} and Epstein, {David L.}",

note = "Funding Information: We gratefully acknowledgem any helpful discussionws ith Dr W. Morton Grant. This study was supportedb y a grant from the National Eye Institute ROl EY05503 and by the National GlaucomaR esearchP rogram,p art of the American Health AssistanceF oundation.",

year = "1990",

month = apr,

doi = "10.1016/0014-4835(90)90142-H",

language = "English (US)",

volume = "50",

pages = "407--418",

journal = "Experimental eye research",

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publisher = "Academic Press",

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T1 - The filtration characteristics of the aqueous outflow system

AU - Johnson, Mark

AU - Johnson, Douglas H.

AU - Kamm, Roger D.

AU - DeKater, Annelies W.

AU - Epstein, David L.

N1 - Funding Information: We gratefully acknowledgem any helpful discussionws ith Dr W. Morton Grant. This study was supportedb y a grant from the National Eye Institute ROl EY05503 and by the National GlaucomaR esearchP rogram,p art of the American Health AssistanceF oundation.

PY - 1990/4

Y1 - 1990/4

N2 - To determine the filtration characteristics of the aqueous outflow system, microspheres (0·18 μm-1·1 μm) were perfused through enucleated human and bovine eyes. The microspheres were smaller than morphologically determined flow dimensions, and yet a significant fraction of all sizes of microspheres were captured. The bovine (calf) aqueous outflow system was found to be a far more efficient filter than was the human outflow system. Combining the experimental results with morphological observations and theoretical calculations leads to the conclusion that 'sticky wall' interactions are responsible for much of the microsphere capture, and that the site of filtration may be distinct from the site of flow resistance. Consequently, the dimension of the sites generating flow resistance cannot be determined from filtration studies.

AB - To determine the filtration characteristics of the aqueous outflow system, microspheres (0·18 μm-1·1 μm) were perfused through enucleated human and bovine eyes. The microspheres were smaller than morphologically determined flow dimensions, and yet a significant fraction of all sizes of microspheres were captured. The bovine (calf) aqueous outflow system was found to be a far more efficient filter than was the human outflow system. Combining the experimental results with morphological observations and theoretical calculations leads to the conclusion that 'sticky wall' interactions are responsible for much of the microsphere capture, and that the site of filtration may be distinct from the site of flow resistance. Consequently, the dimension of the sites generating flow resistance cannot be determined from filtration studies.

KW - bovine

KW - filtration

KW - human

KW - microspheres

KW - trabecular meshwork

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JO - Experimental eye research

JF - Experimental eye research

IS - 4

ER -

The filtration characteristics of the aqueous outflow system

Abstract

Keywords

ASJC Scopus subject areas

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