The five Ps of acute ischemic stroke treatment: Parenchyma, pipes, perfusion, penumbra, and prevention of complications

Robert A. Felberg*, Andrew Naidech

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Stroke is a treatable disease. Despite the therapeutic nihilism of the past, the advent of thrombolysis has changed the way stroke treatment is approached. Acute ischemic stroke is a challenging and heterogeneous disease, and treatment must be based on an understanding of the underlying pathophysiology of ischemia. Interventions are designed to improve neuronal salvage and outcome. The underlying tenets of stroke, therapy focus on the brain parenchyma, arterial flows (pipes), perfusion, the ischemic milieu or penumbra, and prevention of complications. This article focuses on the practical issues of ischemic stroke care with a brief review of supporting literature.

Original languageEnglish (US)
Pages (from-to)5-11
Number of pages7
JournalOchsner Journal
Volume5
Issue number1
StatePublished - Dec 1 2003

ASJC Scopus subject areas

  • Medicine(all)

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