The Fourth International Workshop on Clinical Transplant Tolerance

Fadi Issa, Samuel Strober, Joseph R. Leventhal, Tatsuo Kawai, Dixon B. Kaufman, Josh Levitsky, Megan Sykes, Valeria Mas, Kathryn J. Wood, Nancy Bridges, Lisbeth A. Welniak, Sindhu Chandran, Joren C. Madsen, Peter Nickerson, Anthony J. Demetris, Fadi G. Lakkis, Angus W. Thomson*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

The International Workshop on Clinical Transplant Tolerance is a biennial meeting that aims to provide an update on the progress of studies of immunosuppression minimization or withdrawal in solid organ transplantation. The Fourth International Workshop on Clinical Tolerance was held in Pittsburgh, Pennsylvania, September 5-6, 2019. This report is a summary of presentations on the status of clinical trials designed to minimize or withdraw immunosuppressive drugs in kidney, liver, and lung transplantation without subsequent evidence of rejection. All protocols had in common the use of donor or recipient cell therapy combined with organ transplantation. The workshop also included presentations of mechanistic studies designed to improve understanding of the cellular and molecular basis of tolerance and to identify potential predictors/biomarkers of tolerance. Strategies to enhance the safety of hematopoietic cell transplantation and to improve patient selection/risk stratification for clinical trials were also discussed.

Original languageEnglish (US)
JournalAmerican Journal of Transplantation
DOIs
StateAccepted/In press - 2020

Keywords

  • clinical research/practice
  • clinical trial
  • immune regulation
  • immunosuppression/immune modulation
  • kidney transplantation/nephrology
  • liver transplantation/hepatology
  • tolerance: chimerism
  • tolerance: clinical

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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