The functional consequences of alternative promoter use in mammalian genomes

Ramana V. Davuluri*, Yutaka Suzuki, Sumio Sugano, Christoph Plass, Tim H M Huang

*Corresponding author for this work

Research output: Contribution to journalReview article

222 Scopus citations

Abstract

We are beginning to appreciate the increasing complexity of mammalian gene structure. A phenomenon that adds an important dimension to this complexity is the use of alternative gene promoters that drive widespread cell type, tissue type or developmental gene regulation. Recent annotations of the human genome suggest that almost one half of the protein-coding genes contain alternative promoters, including those of many disease-associated genes. Aberrant use of one promoter over another has been found to be associated with various diseases, including cancer. Here we discuss the functional consequences of use and misuse of alternative promoters in normal and disease genomes and review the molecular mechanisms regulating alternative promoter use in mammalian genomes.

Original languageEnglish (US)
Pages (from-to)167-177
Number of pages11
JournalTrends in Genetics
Volume24
Issue number4
DOIs
StatePublished - Apr 1 2008

ASJC Scopus subject areas

  • Genetics

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    Davuluri, R. V., Suzuki, Y., Sugano, S., Plass, C., & Huang, T. H. M. (2008). The functional consequences of alternative promoter use in mammalian genomes. Trends in Genetics, 24(4), 167-177. https://doi.org/10.1016/j.tig.2008.01.008