The functional neuroanatomy of depression: Distinct roles for ventromedial and dorsolateral prefrontal cortex

Michael Koenigs*, Jordan Grafman

*Corresponding author for this work

Research output: Contribution to journalReview article

452 Scopus citations


A primary aim in the neuroscientific study of depression is to identify the brain areas involved in the pathogenesis of symptoms. In this review, we describe evidence from studies employing various experimental approaches in humans (functional imaging, lesion method, and brain stimulation) that converge to implicate the ventromedial and dorsolateral sectors of prefrontal cortex as critical neural substrates for depression, albeit with distinct functional contributions. The putative roles of ventromedial and dorsolateral prefrontal cortex in depression are discussed in light of the results.

Original languageEnglish (US)
Pages (from-to)239-243
Number of pages5
JournalBehavioural Brain Research
Issue number2
StatePublished - Aug 12 2009



  • Depression
  • Dorsolateral prefrontal cortex
  • Ventromedial prefrontal cortex

ASJC Scopus subject areas

  • Behavioral Neuroscience

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