TY - JOUR
T1 - The functional neuroanatomy of depression
T2 - Distinct roles for ventromedial and dorsolateral prefrontal cortex
AU - Koenigs, Michael
AU - Grafman, Jordan
PY - 2009/8/12
Y1 - 2009/8/12
N2 - A primary aim in the neuroscientific study of depression is to identify the brain areas involved in the pathogenesis of symptoms. In this review, we describe evidence from studies employing various experimental approaches in humans (functional imaging, lesion method, and brain stimulation) that converge to implicate the ventromedial and dorsolateral sectors of prefrontal cortex as critical neural substrates for depression, albeit with distinct functional contributions. The putative roles of ventromedial and dorsolateral prefrontal cortex in depression are discussed in light of the results.
AB - A primary aim in the neuroscientific study of depression is to identify the brain areas involved in the pathogenesis of symptoms. In this review, we describe evidence from studies employing various experimental approaches in humans (functional imaging, lesion method, and brain stimulation) that converge to implicate the ventromedial and dorsolateral sectors of prefrontal cortex as critical neural substrates for depression, albeit with distinct functional contributions. The putative roles of ventromedial and dorsolateral prefrontal cortex in depression are discussed in light of the results.
KW - Depression
KW - Dorsolateral prefrontal cortex
KW - Ventromedial prefrontal cortex
UR - http://www.scopus.com/inward/record.url?scp=67349122031&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67349122031&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2009.03.004
DO - 10.1016/j.bbr.2009.03.004
M3 - Review article
C2 - 19428640
AN - SCOPUS:67349122031
VL - 201
SP - 239
EP - 243
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
IS - 2
ER -