The functional neuroanatomy of depression: Distinct roles for ventromedial and dorsolateral prefrontal cortex

Michael Koenigs; Jordan Grafman

doi:10.1016/j.bbr.2009.03.004

The functional neuroanatomy of depression: Distinct roles for ventromedial and dorsolateral prefrontal cortex

Michael Koenigs^*, Jordan Grafman

^*Corresponding author for this work

Physical Medicine and Rehabilitation

Research output: Contribution to journal › Review article › peer-review

590 Scopus citations

Abstract

A primary aim in the neuroscientific study of depression is to identify the brain areas involved in the pathogenesis of symptoms. In this review, we describe evidence from studies employing various experimental approaches in humans (functional imaging, lesion method, and brain stimulation) that converge to implicate the ventromedial and dorsolateral sectors of prefrontal cortex as critical neural substrates for depression, albeit with distinct functional contributions. The putative roles of ventromedial and dorsolateral prefrontal cortex in depression are discussed in light of the results.

Original language	English (US)
Pages (from-to)	239-243
Number of pages	5
Journal	Behavioural Brain Research
Volume	201
Issue number	2
DOIs	https://doi.org/10.1016/j.bbr.2009.03.004
State	Published - Aug 12 2009

Keywords

Depression
Dorsolateral prefrontal cortex
Ventromedial prefrontal cortex

ASJC Scopus subject areas

Behavioral Neuroscience

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10.1016/j.bbr.2009.03.004

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title = "The functional neuroanatomy of depression: Distinct roles for ventromedial and dorsolateral prefrontal cortex",

abstract = "A primary aim in the neuroscientific study of depression is to identify the brain areas involved in the pathogenesis of symptoms. In this review, we describe evidence from studies employing various experimental approaches in humans (functional imaging, lesion method, and brain stimulation) that converge to implicate the ventromedial and dorsolateral sectors of prefrontal cortex as critical neural substrates for depression, albeit with distinct functional contributions. The putative roles of ventromedial and dorsolateral prefrontal cortex in depression are discussed in light of the results.",

keywords = "Depression, Dorsolateral prefrontal cortex, Ventromedial prefrontal cortex",

author = "Michael Koenigs and Jordan Grafman",

note = "Funding Information: This work was supported in part by the National Institute of Neurological Disorders and Stroke intramural research program, DAMD17-01-1-0675 (J.G.).",

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AU - Grafman, Jordan

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N2 - A primary aim in the neuroscientific study of depression is to identify the brain areas involved in the pathogenesis of symptoms. In this review, we describe evidence from studies employing various experimental approaches in humans (functional imaging, lesion method, and brain stimulation) that converge to implicate the ventromedial and dorsolateral sectors of prefrontal cortex as critical neural substrates for depression, albeit with distinct functional contributions. The putative roles of ventromedial and dorsolateral prefrontal cortex in depression are discussed in light of the results.

AB - A primary aim in the neuroscientific study of depression is to identify the brain areas involved in the pathogenesis of symptoms. In this review, we describe evidence from studies employing various experimental approaches in humans (functional imaging, lesion method, and brain stimulation) that converge to implicate the ventromedial and dorsolateral sectors of prefrontal cortex as critical neural substrates for depression, albeit with distinct functional contributions. The putative roles of ventromedial and dorsolateral prefrontal cortex in depression are discussed in light of the results.

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KW - Dorsolateral prefrontal cortex

KW - Ventromedial prefrontal cortex

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The functional neuroanatomy of depression: Distinct roles for ventromedial and dorsolateral prefrontal cortex

Abstract

Keywords

ASJC Scopus subject areas

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